Research Article | Volume: 5, Issue: 1, January, 2015
Research Article | Volume: 5, Issue: 1, January, 2015
Unani system of medicine is gaining popularity day by day owing to its efficiency, low cost, availability and to the safety of its formulations and drugs/medicines. The current study was aimed to determine the safety of a polyherbal Unani formulation named Deedan. A suspension of powdered Deedan at the dose of 300mg/kg of b. wt was orally administered to the male and female group of rats (n=5) for 90 days daily and then sacrificed. The biochemical and hematological parameters of treated rats were compared with respective control group of rats. Various vital organs/tissues were collected, examined, weighed and tissue samples were taken for histopathological studies of both the treated and control groups. Physiological parameters like water and feed consumption were also observed in all the groups. The treated rats (both males and females) were found to gain bodyweight normally. There was no effect of the drug on biochemical and hematological parameters as the changes were statistically insignificant. The histopathological studies revealed the normal appearance of tissues. The feed and water consumption in treated group of rats was found to be unaffected by the drug administration. The drug deedan was found to be safe at the dose of 300 mg/kg of body weight when administered orally to the rats for 90 days.
Khalid Ghazanfar, Showkat A. Dar, Tazeen Nazir, Irfat Ara Akbar Masood, and Seema Akbar. Safety evaluation of polyherbal Unani formulation-Deedan in Wistar rats. J App Pharm Sci, 2015; 5 (01): 089-093.
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