Research Article | Volume: 5, Issue: 1, January, 2015

Chemical Composition, Antiviral against avian Influenza (H5N1) Virus and Antimicrobial activities of the Essential Oils of the Leaves and Fruits of Fortunella margarita, Lour. Swingle, Growing in Egypt

Nabaweya A. Ibrahim,  Seham S. El-Hawary,  Magdy M. D. Mohammed,  Mohamed A. Farid,  Nayera A. M. AbdelWahed,  Mohamed A. Ali,  Eman A. W. El-Abd   
Nabaweya A. Ibrahim1, Seham S. El-Hawary2, Magdy M. D. Mohammed1, Mohamed A. Farid3, Nayera A. M. AbdelWahed3, Mohamed A. Ali4, Eman A. W. El-Abd1

1Pharmacognosy Department, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki-12311, Cairo, Egypt.

2Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza, Egypt.

3Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki-12311, Cairo, Egypt.

4Center of Scientific Excellence for Influenza Viruses, National Research Center, Dokki-12311, Cairo, Egypt.

Open Access   

Published:  Jan 30, 2015

DOI: 10.7324/JAPS.2015.50102
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Abstract

Essential oils of the fresh leaves and fruits of Fortunella margarita Lour. Swingle (Family: Rutaceae) were prepared by hydrodistillation method, which resulted with 0.27 and 0.30% respectively. The resulted oils of both organs were analyzed by GC/MS which revealed the presence of twenty compounds in the leaves oil representing 86.96% of the oil, from which gurjunene, eudesmol and muurolene were identified as major compounds. The fruit’s oil was found to contain fourteen compounds representing 77.77% of the oil, of which terpineol, t-carveol, limonene, muurolene and cadinene represented the major compounds. The antiviral activity of the essential oils of both leaves and fruits was tested against avian influenza-A virus (H5N1), and the results revealed higher potency of fruits oil. Moreover, the essential oils of the leaves and fruits were investigated for their antimicrobial and antifungal activities. The oil of the leaves showed antimicrobial activity higher than that of the fruits at dilution (1:50 v/v) against Bacillus subtilis, Staphylococcus aureus, Sarcina luta and Streptococcus faecalis, also it has a moderate activity against Escherichia coli, Klebsilla pneumonia and Pseudomonas aeroginosa. On the other hand, the antifungal activity of the leaves and fruits revealed that the fruits exhibited higher activity than that of the leaves against Aspergillus niger and Candida albicans.


Keyword:     Fortunella margarita Lour. Swingle Rutaceae essential oil antiviral antimicrobial.

Citation:

Nabaweya A. Ibrahim, Seham S. El-Hawary, Magdy M. D. Mohammed, Mohamed A. Farid, Nayera A. M. Abdel-Wahed, Mohamed A. Ali, Eman A. W. El-Abd. Chemical Composition, Antiviral against avian Influenza (H5N1) Virus and Antimicrobial activities of the Essential Oils of the Leaves and Fruits of Fortunella margarita, Lour. Swingle, Growing in Egypt. J App Pharm Sci, 2015; 5 (01): 006-012.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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