Research Article | Volume : 1 Issue : 6, August 2011

Bioequivalence studies on some selected brands of

ciprofloxacin hydrochloride tablets in the Nigerian

market with ciproflox® as innovator brand

Osonwa Uduma E. Agboke Ayodeji A. Amadi Rosemary C. OkorieOgbonna Opurum Christian C   

Open Access   


This work assesses the bioequivalence of four selected brands of ciprofloxacin hydrochloride in the Nigerian market to Ciproflox® as a selected innovator brand. The brands selected were reperesented by samples A, B, C and D all are of Asian origin. The following parameters were employed in the assay- Weight uniformity, tablet hardness, friability, disintegration time and dissolution profile in 0.1N HCl , and minimum inhibitory concentration (MIC) determined by zones of inhibition on clinical isolates of Staphylococcus aureus. The mean hardness results were in the order Ciproflox(R) (14.55 ± 3.97) > C (12.51 ± 3.01) > D (9.87 ± 2.38) > B (9.67 ± 1.37) > A (8.98 ± 3.46) and they all fell within the acceptable values of 3 kgs =.hardness. The mean friability results were in the order A (0.07)

Keyword:     Ciprofloxacin hydrochloridetabletsbrandsbioequivalencetablet characteristicsmicrobiological.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics

393 Absract views 22 PDF Downloads 415 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required