Research Article | Volume: 4, Issue: 6, June, 2014

Study on the effect of different polymers on in-vitro dissolution profile of Fenofibrate by solid dispersion technique

S M Moazzem Hossen Raihan Sarkar Md. Hasan Abdullah Towhid Md. Tipu Sultan and N. M. Abdul Aziz   

Open Access   

Published:  Jun 28, 2014

DOI: 10.7324/JAPS.2014.40608
Abstract

Fenofibrate is a poor water soluble drug having poor rate of dissolution. In this research work we tried to enhance dissolution of fenofibrate by following solid dispersion of fenofibrate formulations with different dissolution enhancing polymers likeHPMC 6cps, Poloxamer 188, Poloxamer 407, PEG 6000. Total twenty four formulations were prepared with this polymers in single or combinations. If the solid dispersion is first, other parameters like dissolution, bioavailability will be first. Dissolution of all the formulations were tested for % drug release profile, mean dissolution time, assay and uniformity of drug content and % recovery was calculated. From all formulations, F3, F5, F6, F9, F10, F12 and F14 shows greater dissolution of fenofibrate 93.64%, 83.66%, 100.53%, 100.61%, 100.95% and 83.06% respectively within 60 minutes of dissolution and also decreases the mean dissolution time. Based on in-vitro dissolution results and drug release model kinetics, we can decide that these formulations are able to increase the dissolution as well as can increase the absorption rate and bioavailability of fenofibrate. Finally we can conclude that, these formulations enhance the dissolution and bioavailability of Fenofibrate and good formulation candidates for Fenofibrate in future.


Keyword:     Fenofibrate solid dispersion PEG Poloxamer HPMC MDT bioavailability.


Citation:

S M Moazzem Hossen, Raihan Sarkar, Md. Hasan Abdullah Towhid, Md. Tipu Sultan and N. M. Abdul Aziz. Study on the effect of different polymers on in-vitrodissolution profile of Fenofibrate by solid dispersion technique. J App Pharm Sci, 2014; 4 (06): 056-060.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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