Research Article | Volume: 4, Issue: 6, June, 2014

Effect of Coenzyme Q10 Supplementation on Markers of Oxidative Stress in Streptozotocin Induced Diabetic Rats

Mona AnwarMehrevan Abd El-MoniemHoda A MegahedSafinaz E EL-ToukhyNadia A MohammedEman R Youness   

Open Access   

Published:  Jun 28, 2014

DOI: 10.7324/JAPS.2014.40602
Abstract

Increasing evidences link free radicals and oxidative stress to the pathogenesis of diabetes and related complications. The aim of this study was to investigate the effects of exogenous coenzyme Q10 supplementation on streptozotocin induced experimental diabetes in rats. Experimental diabetes was induced by single subcutaneous injection of streptozotocin ( 50 mg/kg/ body weight) . Forty male albino rats were used in this study, they were divided into 4 groups: control group, coenzyme Q10 treated group, diabetic group and coenzyme Q10 treated diabetic group. At the end of the experiment (8 weeks) urine samples were collected, rats were sacrificed and blood samples were collected for biochemical analysis. Significant high levels of blood sugar, glycated Hb, total cholesterol, triglyceride, LDL cholesterol, advanced oxidative protein products , 8-hydroxy-2-deoxyguanosine and percent of DNA damage as well as significant low levels of nitric oxide and HDL cholesterol were observed in diabetic group. Significant low levels of blood sugar, glycated Hb, cholesterol, triglyceride, LDL cholesterol, advanced oxidative protein products, 8-hydroxy-2-deoxyguanosine and percent of DNA damage as well as significant high levels of nitric oxide and HDL cholesterol were observed in coenzyme Q10 treated diabetic group. The data confirmed the property of coenzyme Q10 as an antioxidant that ameliorates oxidative stress and that it may be used as an additional therapeutic agent for prophylaxis and slowing down the progression diabetic complications.


Keyword:     Oxidative stress coenzyme Q10 streptozotocin diabetes.


Citation:

Mona Anwar, Mehrevan Abd El-Moniem, Hoda A Megahed, Safinaz E EL-Toukhy, Nadia A Mohammed, Eman R Youness. Effect of Coenzyme Q10 Supplementation on Markers of Oxidative Stress in Streptozotocin Induced Diabetic Rats. J App Pharm Sci, 2014; 4 (06): 009-015.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics

717 Absract views 16 PDF Downloads 733 Total views

   Abstract      Pdf Download

Related Search

By author names

Citiaion Alert By Google Scholar

Name Required
Email Required Invalid Email Address

Comment required