Research Article | Volume: 4, Issue: 5, May, 2014

In vivo antioxidant and antigenotoxic evaluation of an enaminone derivative BDHQ combined with praziquantel in uninfected and Schistosoma mansoni infected mice

Jehane I. Eid Aliaa R. Mohammed Nahed A. Hussien Amal M. E-Shennawy Magda M. Noshy Mohamed Abbas   

Open Access   

Published:  May 27, 2014

DOI: 10.7324/JAPS.2014.40505
Abstract

Chemotherapy with praziquantel is the cornerstone of schistosomiasis control, but an oxidative/nitrative stress may occur after short-term treatment and participate in side effects. The aim of this study was to evaluate the antioxidant and antigenotoxic effects of the novel antischistosomal enaminone derivative, 4–hydroxyquinoline (BDHQ), alone or combined with PZQ, in hepatic tissues of uninfected and Schistosoma mansoni infected mice. Uninfected untreated control mice and infected mice were treated with 0 or 500 mg/kg PZQ, 600 mg/kg BDHQ, or PZQ (250 mg/kg) combined with BDHQ (300 mg/kg) for 2 consecutive days. The studied biomarkers, related to oxidative/nitrosative stress and DNA damage were significantly improved in infected mice treated with BDHQ combined with PZQ as compared to either drug alone. This amelioration was accompanied with reduction in hepatic granuloma size and histopathologic lesions. Furthermore, we documented a novel PZQ-induced mutation of hepatic mitochondrial genome in uninfected animals.


Keyword:     Schistosomiasis praziquantel BDHQ mtDNApoint mutation nitrosative stress.


Citation:

Jehane I. Eid, Aliaa R. Mohammed, Nahed A. Hussien, Amal M. EShennawy, Magda M. Noshy, Mohamed Abbas., In vivo antioxidant and genotoxic evaluation of an enaminone derivative BDHQ combined with praziquantel in uninfected and Schistosoma mansoni infected mice. J App Pharm Sci, 2014; 4 (05): 025-033.

Conflict of Interest: None declared.

Source of support: None declared.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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