Research Article | Volume: 4, Issue: 4, April, 2014

An evaluation of the metabolic effects of antipsychotic medications in patients suffering from psychiatric illness

Nimit Nitinkumar Goswami Anuradha M Gandhi Prakruti P Patel Ram Kumar Dikshit   

Open Access   

Published:  Apr 28, 2014

DOI: 10.7324/JAPS.2014.40403
Abstract

Present study evaluates the effects of antipsychotic medications on metabolic parameters in patients suffering from psychiatric illness. The study was carried out at tertiary care teaching hospital, department of psychiatry after obtaining written informed consent from the patients. They were randomized into three groups - Group I (n=31) (haloperidol 10 mg/day, orally), Group II (n=34) (risperidone 4-6 mg/day, orally) and Group III (n=38) (olanzapine 10 mg/day, orally). Metabolic parameters [fasting blood sugar (FBS), post prandial blood sugar (PP2BS), glycosylated haemoglobin (HbA1c), serum cholesterol, triglyceride, low density lipoprotein (S.LDL) and high density lipoprotein (S.HDL)] were measured at the end of 3 and 6 months. Data was analysed using a suitable statistical tests. In group II significant changes (p<0.05) were observed in FBS, HBA1C, cholesterol, S.LDL and S.HDL while in group III significant changes (p<0.05) were observed in all the metabolic parameters at the end of 6 months. In group III, FBS, PP2BS, HbA1C, Serum cholesterol, triglyceride and S.LDL levels were increased 9.41%, 7.09%, 8%, 6.25%, 7.68% and 9.92% respectively, at the end of 6 months. Patients treated with haloperidol showed minimum changes in metabolic parameters at the end of 6 months. Olanzapine is associated with more disturbances in metabolic parameters as compared to risperidone and haloperidol.


Keyword:     Metabolic effects psychiatric illnesses olanzapine risperidone haloperidol.


Citation:

Nimit Nitinkumar Goswami, Anuradha M Gandhi, Prakruti P Patel, Ram Kumar Dikshit. An evaluation of the metabolic effects of antipsychotic medications in patients suffering from psychiatric illnes. J App Pharm Sci, 2014; 4 (04): 014-019.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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