Research Article | Volume: 4, Issue: 4, April, 2014
Research Article | Volume: 4, Issue: 4, April, 2014
Strain BT01 was isolated from the root tissue of Boesenbergia rotunda (L.) Mansf. and identified as Streptomyces sp. on the basis of morphology, chemotaxonomy and 16SrDNA sequencing. It was an antagonist of Gram positive bacteria; Staphylococcus aureus ATCC25932, Bacillus cereus ATCC7064 and Bacillus subtilis ATCC6633. The inhibitory effect of the crude extract from the strain BT01 was examined based on the paper disc diffusion method (5 mg per paper disc) with three replications. It has been shown to have antibacterial activity. The major active ingredients from the crude extract were purified by silica gel column chromatography, thin-layer chromatography and identified to be two new flavonoids, 7-methoxy-3, 3',4',6-tetrahydroxyflavone (1) and 2',7-dihydroxy-4',5'-dimethoxyisoflavone (4), together with four known compounds, fisetin (2), naringenin (3), 3'-hydroxydaidzein (5) and xenognosin B (6). Bioassay studies showed that these compounds had antibacterial activity with the minimum inhibitory concentrations within the range of 32 to 256 µg/ml.
Thongchai Taechowisan, Srisakul Chanaphat, Wanwikar Ruensamran, and Waya S. Phutdhawong., Antibacterial activity of new flavonoids from Streptomyces sp. BT01; an endophyte in Boesenbergia rotunda (L.) Mansf. J App Pharm Sci, 2014; 4 (04): 008-013.
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