Research Article | Volume: 4, Issue: 3, March, 2014

Bioadhesive buccal gels impregnated with fluconazole: formulation, in vitro and ex vivo characterization

Preeti K. Suresh and Sanju Manhar   

Open Access   

Published:  Feb 27, 2014

DOI: 10.7324/JAPS.2014.40304
Abstract

This study describes the formulation of bioadhesive buccal gels for fluconazole delivery via buccal mucosa. In the present study the polymer with well-defined mucoadhesive properties like Carbopol 934 was used. Carbopol-Poloxamer gels of 1% fluconazole was formulated with various absorption enhancers like polyethylene glycol, propylene glycol, glycerol, phosphatidylcholine, mannitol and sodium lauryl sulphate by cold method. The gels were characterised for gelation temperature, bioadhesive force, pH, viscosity, drug release profile, ex vivo permeation across goat buccal mucosa and stability profile. The percent drug permeated through the buccal mucosa was in the range of 62-76%. Polyethylene glycol and propylene glycol were found to be better absorption enhancers as compared to others and followed zero order release kinetics.


Keyword:     Mucoadhesive bioadhesion fluconazole oral candidiasis residence time.


Citation:

Preeti K. Suresh and Sanju Manhar. Bioadhesive Buccal Gels Impregnated with Fluconazole: Formulation, In Vitro And Ex Vivo Characterization. J App Pharm Sci, 2014; 4 (03): 015-019.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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