Research Article | Volume: 4, Issue: 3, March, 2014

Bioavailability of karanjin from Pongamia pinnata L. in Sprague dawley rats using validated RP-HPLC method

Naresh Shejawal Sasikumar Menon Sunita Shailajan   

Open Access   

Published:  Feb 27, 2014

DOI: 10.7324/JAPS.2014.40303
Abstract

Pongamia pinnata L. (fabaceae) is a small evergreen tree reported in traditional literature as ‘Karanj’. Seeds of this plant have been used in the management of skin diseases, ulcer, piles, bronchitis; leprosy etc. Seeds are reported to possess phytoconstituents like pongapin, pongamol, pongaglabrone, kanjone, karanjin etc. The therapeutic activities of seeds are mainly attributed to its major furanoflavone karanjin. Thus, in the present research work the pharmacokinetics of karanjin was determined in Sprague dawley female rats using a validated RP-HPLC method from the ethanolic extract of P. pinnata (p.o.). The pharmacokinetic parameters were calculated using non compartmental model of analysis. Findings of the present work would be applicable for the future investigation on P. pinnata and karanjin for their different therapeutic uses and would be useful for justifying their dosage and route of administration from their allied formulations.


Keyword:     Pongamia pinnata L. karanjin pharmacokinetics RP-HPLC Raughan-e-Karanj.


Citation:

Naresh Shejawal, Sasikumar Menon, Sunita Shailajan. Bioavailability of karanjin from Pongamia pinnata L. in Sprague dawley rats using validated RP-HPLC method. J App Pharm Sci, 2014; 4 (03): 010-014.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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