Research Article | Volume: 4, Issue: 1, January, 2014

Design, synthesis and evaluation of Schiff bases & thiazolidinone derivatives for anticonvulsant activity

Nikhil Batra Shikha Batra Badri Prakash Nagori   

Open Access   

Published:  Jan 30, 2014

DOI: 10.7324/JAPS.2014.40118
Abstract

A series of 2-oxo-N'-phenylmethylidene-2H-chromene-3-carbohydrazides and their thiazolidinone derivatives were designed on the basis of pharmacophoric distance mapping study of well established anticonvulsant drugs. In another computational study, pharmacokinetic parameters of designed compounds were predicted using Molinspiration Online Property Calculation Toolkit. Structures of all the compounds were confirmed by spectroscopical data. Compounds were evaluated for neurotoxicity by rotorod test. Anticonvulsant activity of test compounds was evaluated by maximal electroshock seizure (MES) animal model of seizures. Test compounds CS-6 and CST-6 were found to possess potent anticonvulsant activity and served as the prototype molecules of the series.


Keyword:     Schiff bases thiazolidinone CNS activity anticonvulsant epilepsy.


Citation:

Nikhil Batra, Shikha Batra, Badri Prakash Nagori. Design, synthesis and evaluation of Schiff bases & thiazolidinone derivatives for anticonvulsant activity. J App Pharm Sci, 2014; 4 (01): 105-112.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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