Design, synthesis and evaluation of Schiff bases & thiazolidinone derivatives for anticonvulsant activity

A series of 2-oxo-N'-phenylmethylidene-2H-chromene-3-carbohydrazides and their thiazolidinone derivatives were designed on the basis of pharmacophoric distance mapping study of well established anticonvulsant drugs. In another computational study, pharmacokinetic parameters of designed compounds were predicted using Molinspiration Online Property Calculation Toolkit. Structures of all the compounds were confirmed by spectroscopical data. Compounds were evaluated for neurotoxicity by rotorod test. Anticonvulsant activity of test compounds was evaluated by maximal electroshock seizure (MES) animal model of seizures. Test compounds CS-6 and CST-6 were found to possess potent anticonvulsant activity and served as the prototype molecules of the series.