Research Article | Volume: 3, Issue: 12, December, 2013

Synthesis and Evaluation of new Ethyl N-[(Z)-(2-Oxo-5-Sulfamoyl-Indolin-3-Ylidene) Amino] Carbamate Derivatives for their Antimicrobial and Anti-inflammatory Activity

Srikanth Lingala Kiran Samudrala Raghunandan Nerella   

Open Access   

Published:  Dec 30, 2013

DOI: 10.7324/JAPS.2013.31217

In view of various biological activities and enormous importance of indoles, isatins and their derivatives, it was our interest to synthesize and characterize some new 5-Sulfamoyl Isatin derivatives and evaluate them for antimicrobial and anti-inflammatory activity. An appropriate quantity of isatin hydrazone was heated under reflux with ethylchloroformate to give ethyl n-[(z)-(2-oxo-5-sulfamoyl-indolin-3-ylidene)amino]carbamate which was then heated under reflux with various primary amines to give ethyl n-[(z)-(2-oxo-5-sulfamoyl-indolin-3-ylidene) amino]carbamate derivatives. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the synthesized compounds were screened for antibacterial activity against B. subtilis, B.cereus, S. epidermidis, S. typhi, P. aeruginosa and K. pneumoniae, antifungal activity against A. flavus, F. oxysporium and P. notatum and anti-inflammatory activity using carrageenan induced rat paw edema model. Most of the compounds tested have shown promising activities when compared with the standard drugs.

Keyword:     Isatins Antimicrobial activity Anti inflammatory activity Amikacin Amphoterecin.


Srikanth Lingala, Kiran Samudrala, Raghunandan Nerella., Synthesis and Evaluation of new Ethyl N-[(Z)-(2-Oxo-5- Sulfamoyl-Indolin-3-Ylidene) Amino]Carbamate Derivatives for their Antimicrobial and Anti- Inflammatory Activity. J App Pharm Sci, 2013; 3 (12): 093-098.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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