Research Article | Volume: 6, Issue: 2, February, 2016

A comparative study of the effect of amikacin administered through autoinjector and manual injection on biochemical parameters in rats

Anitha Roy R. Vijayaraghavan R. V. Geetha Anitha Magesh S. Vishnu Priya Anusha Ramasamy U Vidyalakshimi K RaagaNamrata S. Krishna Mohan Madhan Chakkaravarthy   

Open Access   

Published:  Feb 27, 2016

DOI: 10.7324/JAPS.2016.60216
Abstract

Objective: The objective was to compare the biochemical changes of amikacin by autoinjector delivery and manual injection in rats.

Materials and Methods: Amikacin drug cartridge (500 mg/2 mL) for autoinjectors was diluted to 63 mg/mL and rats were administered 1.2 mL, i.p. One group was given 3 and a second group 7 injection on consecutive days. 3 and 7 days manual injection of same dose of amikacin (about 500 mg/kg, i.p.) and a control group (saline) were also included (total 5 groups). On day 4 or 8 biochemical parameters were studied.

Results: Significant increase in urea, creatinine and aspartate aminotransferase were observed in 7 days administration in both autoinjector and manual injection groups compared to control group. All other parameters viz., glucose, cholesterol, total triglycerides, bilirubin, uric acid, total protein, albumin, alanine aminotransferase and alkaline phosphatase did not show any significant change. No significant change was observed in 3 days administration groups.

Conclusion: High dose of amikacin for longer duration is known for its nephrotoxicity which is evidenced by the increase in urea and creatinine in both autoinjector and manual injection groups. This study shows that autoinjector device for amikacin which is new can be considered for further research work.


Keyword:     Nephrotoxicity creatinine urea Amikacin autoinjector biochemical parameters.


Citation:

Anitha R, Vijayaraghavan R, Geetha RV, Anitha M, Vishnu Priya S, Anusha R, Vidyalakshimi U, RaagaNamrata K, Krishna Mohan S, Chakkaravarthy M. A comparative study of the effect of amikacin administered through autoinjector and manual injection on biochemical parameters in rats. J App Pharm Sci, 2016; 6 (02): 109-114.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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