Research Article | Volume: 3, Issue: 10, October, 2013

Prolonged-release lipid microparticles prepared with decyl oleate and hydrogenated castor oil of ibuprofen

Felipe Cardoso Rodrigues Vieira Maria Helena dos Anjos Rodrigues Amaral and Paulo Alexandre Lourenço Lobão   

Open Access   

Published:  Oct 31, 2013

DOI: 10.7324/JAPS.2013.31002
Abstract

Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best excipients and the most suitable pharmaceutical dosage form to carry ibuprofen is very important for the industrial success of this drug. Given these factors, lipid microparticles of ibuprofen with decyl oleate and hydrogenated castor oil were prepared. This formulation was intended to improve the content of ibuprofen in preparation and to sustain the release of this drug. Lipid microparticles were submitted to determination of ibuprofen content using UV-VIS spectrophotometry and, gelatin capsules filled with lipid microparticles and tablets prepared with these microparticles were submitted to dissolution tests in order to study the influence of the prepared system in the release profiles of ibuprofen. The improvement of the content of ibuprofen and prolonged release of this drug was achieved with the lipid microparticles prepared with this mixture of excipients.


Keyword:     Ibuprofen Lipid microparticles Decyl oleate Hydrogenated castor oil.


Citation:

Felipe Cardoso Rodrigues Vieira, Maria Helena dos Anjos Rodrigues Amaral and Paulo Alexandre Lourenço Lobão. Prolonged-release lipid microparticles prepared with decyl oleate and hydrogenated castor oil of ibuprofen. J App Pharm Sci, 2013; 3 (10): 008-010.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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