Review Article | Volume: 3, Issue: 9, September, 2013

Low molecular weight thiols: glutathione (GSH), mycothiol (MSH) potenail antioxidant compound from actinobacteria

Anita Garg Bhavana soni Balwant Singh Paliya Smarti Verma Vishwjeet Jadaun   

Open Access   

Published:  Sep 30, 2013

DOI: 10.7324/JAPS.2013.3921

The class of Actinobacteria is a large group of gram-positive bacteria and having high G+C content. Actinobacteria also produced curious compound like thiols mainly Mycothiol (MSH) and Glutathione (GSH). MSH is also known as mycothiol and comprised of a cysteine residue with an acetylated amino group which is linked to glucosamine to inositol but Glutathione (GSH) having gamma peptide linkage between cysteine group which is attached by normal peptide linkage to a glycine and the carboxyl group of the glutamate side-chain. These thiols play a key role in maintaining a reducing environment in the cell, which is necessary for regular metabolic activities and represent adaptation under stress condition for survival of organisms. Both Mycothiol and glutathione (GSH) having property to protect cells against oxygen toxicity but MSH shows 7 fold slower ability to resistance of autoxidation compare to GSH but GSH is absent in archaebacterium and rarely found in Streptomycetes strains (Streptomyces lactamdurans). In this review article we discussed about the GSH and MSH structure, properties and how GSH is better than MSH in the case of antioxidant production.

Keyword:     Glutathione (GSH) Mycothiols (MSH) Actinobacteria


Anita Garg, Bhavana soni, Balwant Singh Paliya, Smarti Verma, Vishwjeet Jadaun. Low molecular weight thiols: glutathione (GSH), mycothiol (MSH) potenail antioxidant compound from actinobacteria. J App Pharm Sci, 2013; 3 (09): 117-120.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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