Research Article | Volume: 3, Issue: 8, Supplement: 1, September, 2013

Evaluation of Starch From New Sweet Potato Genotypes for use as A Pharmaceutical Diluent, Binder or Disintegrant

Marcel Tunkumgnen Bayor Eric Tuffour Paul Salo Lambon   

Open Access   

Published:  Sep 18, 2013

DOI: 10.7324/JAPS.2013.38.S4
Abstract

Starches from four new sweet potato genotypes were evaluate for use as tablet diluents, binders and disintegrants; using a commercially available maize starch as reference. The pre-formulation studies established low pH (5.1 - 5.9) and moisture content (10.0 - 13.1%), but high bulk density (0.50 - 0.58), tapped density (0.75 - 0.82) and true density (1.15 - 1.18) for the sweet potato starches. Hardness and friability of tablets formulated with sweet potato starches as binder were significantly better (p = 0.001) than similar compacts containing maize starch. The sweet potato starches also caused significantly faster tablet disintegration and release of paracetamol (p = 0.005). The results established the sweet potato starches as stronger pharmaceutical diluents, binders and disintegrants, compared to the commercially available maize starch.


Keyword:     Sweet potato genotype starch excipient diluent binder disintegrant.


Citation:

Marcel Tunkumgnen Bayor, Eric Tuffour, Paul Salo Lambon. Evaluation of Starch From New Sweet Potato Genotypes for use as A Pharmaceutical Diluent, Binder or Disintegrant. J App Pharm Sci, 2013; 3 (8 Suppl 1): S17-S23.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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