Research Article | Volume: 3, Issue: 8, August, 2013

Antiulcerogenic potential of Salvia officinalis L. extract in rats

Taís Regina Fiorentin Michela Bianchi De Mello Aline Maria Krube Aquino Bruna Alexsandra Rigo Carla Giane Loss Melissa Schwanz Arno Ernesto Hofmann Junior Sandra Manoela Dias Macedo   

Open Access   

Published:  Aug 30, 2013

DOI: 10.7324/JAPS.2013.3806
Abstract

The objective of this paper was to evaluate the antiulcer activity of a crude ethanol extract of Salvia officinalis L. in a gastric lesion induction model. Male Wistars rats were housed in groups of five and fasted 12 hours before the experiment, receiving only water ad libitum. The experimental groups received oral doses of 50, 75, 100 and 150 μg/kg of the extract and the negative and positive control groups received distilled water and omeprazol (30mg/kg), respectively. One hour after each respective oral dose, the ulcer was induced with absolute ethanol. a further hour after induction, the animals were euthanized by CO2 camera, the stomachs removed and opened along the greater curvature. Data was statistically analysed using analysis of variance (ANOVA) followed by the Tukey method (p<0.05). The groups treated with Salvia officinalis L. extract at doses of 100 and 150 μg/kg showed significant changes in the four parameters evaluated. By reducing the total lesion area, a significant increase in the cure ratio was observed, suggesting a gastroprotective effect of the extract. This data demonstrates the potential use of Salvia officinalis L. extract for effective treatment of injuries caused by absolute ethanol.


Keyword:     Salvia officinalis L. antiulcerogenic rats ethanol.


Citation:

Taís Regina Fiorentin, Michela Bianchi De Mello, Aline Maria Krube Aquino, Bruna Alexsandra Rigo, Carla Giane Loss, Melissa Schwanz, Arno Ernesto Hofmann Junior, Sandra Manoela Dias Macedo., Antiulcerogenic potential of Salvia officinalis L. extract in rats. J App Pharm Sci, 2013; 3 (08): 032-035.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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