Research Article | Volume: 3, Issue: 7, July, 2013

Evaluation of Cardioprotective Activity of Aqueous and Ethanolic Extract of Bauhinia Variegata in Cacl2 Induced Arrhythmia in Albino Rats

Rajesh Kumar Sharma Ashish Kumar Sharma Govind Mohan   

Open Access   

Published:  Jul 30, 2013

DOI: 10.7324/JAPS.2013.3732
Abstract

The aim of present study was to evaluate cardioprotective activity of ethanolic and aqueous extracts of Bauhinia variegata Linn in CaCl2 induced arrhythmia in albino rats.In present study, i.v injection of 5% CaCl2 solution (25 mg/kg b.w.) that induce arrhythmia without causing mortality and heart rates were monitored throughout the study by a lead II electrocardiogram. CaCl2 reduced heart rate and exhibited alteration in the PQRST waves. Arrhythmia induced by CaCl2 in experimental animals, which is confirmed by change in ECG pattern and sodium, potassium and calcium level in plasma. Pretreatment of extracts prevent the CaCl2 induced arrhythmia by virtue of the potent active constituents. Bauhinia variegata Linn. root extracts produced significantly (P


Keyword:     Bauhinia variegata Linn. Electrocardiogram Myocardial fibers Varapamil Ventricular fibrillation.


Citation:

Rajesh Kumar Sharma, Ashish Kumar Sharma, Govind Mohan. Evaluation of Cardioprotective Activity of Aqueous and Ethanolic Extract of Bauhinia Variegata in Cacl2 Induced Arrhythmia in Albino Rats. J App Pharm Sci. 2013; 3 (07): 169-173.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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