Research Article | Volume: 3, Issue: 7, July, 2013

Protective and therapeutic activities of Mayodendron igneum Kurz against paracetamol induced liver toxicity in rats and its bioactive constituents

Manal H. Shabana Fatma A.M. Hashem Abdel-Naser Singab Sally Khaled and Abdel-Razik Farrag   

Open Access   

Published:  Jul 30, 2013

DOI: 10.7324/JAPS.2013.3728
Abstract

The total ethanol extract of Mayodendron igneum leaves and its successive extracts (pet. Ether, chloroform and ethyl acetate combined with ethanol )were examined for their protective and therapeutic effects against paracetamol induced liver damage in rats. The evaluation was done through measuring the liver function enzymes; aspartate and alanine aminotransferases (AST and ALT) as well as cholestatic marker; alkaline phosphatase ( ALP). Liver histopathological analysis were also evaluated. Treatment with the selected extacts significantly decreased AST, ALT and ALP.The biochemical results were in accordance with histopatholical results. From the successive ethyl acetate extact, three flavonoids were isolated, purified and identified as 6-methoxyapigenin; fisetin-3-O-β-glucopyranoside and 3-methoxyquercetin-7-O-β-glucopyranoside(6→8”)3”-methoxykaempferol-7”-O-β-glucopyranoside. Five phytoconstituents were isolated from successive ethanol extract and were identified as 4-methoxybenzoic acid; 6,7-dihydroxycoumarin; apigenin-7-O-β-neohesperidoside; 6 –methoxyluteolin-7-O-β-neohesperidoside and luteolin-7-O-β-neohesperidoside. Mayodendron leaves extracts resulted in an attractive candidate for the protection and the treatment of liver damage induced by paracetamol.The flavonoids and coumarin present in the plant may be responsible for the pharmacological activity.


Keyword:     Mayodendron igneum leaves phenol


Citation:

Manal H. Shabana, Fatma A.M. Hashem, Abdel-Naser Singab, Sally Khaled and Abdel-Razik Farrag., Protective and therapeutic activities of Mayodendron igneum Kurz against paracetamol induced liver toxicity in rats and its bioactive constituents. J App Pharm Sci, 2013; 3 (07): 147-155.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
418 Views 9 Downloads 427 Total

Year

Month

Related Search

By author names