Research Article | Volume: 3, Issue: 7, July, 2013

New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization

M. Jagadeesha V. Asha Kumara C. Ramachandraiahb A. Varada Reddya   

Open Access   

Published:  Jul 30, 2013

DOI: 10.7324/JAPS.2013.3721

Three new chalcogenic thiosemicarbazones (3,4-difluoroacetophenone thiosemicarbazone(1), 2-bromo-4’-chloroacetophenone thiosemicarbazone(2) and 2, 4’-dibromoacetophenone thiosemicarbazone(3) are synthesized by using a conventional one step processes in which the respective halo-substituted acetophenones are condensed with thiosemicarbazide to result in the formation of the product. The chalcogenic thiosemicarbazones are then characterized by the spectroscopic techniques like FT-IR, FT-Raman, UV-Vis, 1H and 13C NMR (19F for 1), HR-MS and LC-MS, TG-DTA. The compound 1 is unambiguously characterized by single crystal X-ray diffraction and is found to have monoclinic system. These compounds were further tested for their antimicrobial activity against some human pathogens like E. coli, B. subtilis, P. aureginosa and S. aureus. The MIC values have suggested that these are potential antimicrobial agents.

Keyword:     Chalcogenic thiosemicarbazones sulphur organic compounds antimicrobial activity.


M. Jagadeesh, V. Asha Kumar, C. Ramachandraiah, A. Varada Reddy., New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization. J App Pharm Sci, 2013; 3 (07): 111-115.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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