Research Article | Volume: 3, Issue: 7, July, 2013
Research Article | Volume: 3, Issue: 7, July, 2013
For this experiment, Oleic Acid and Cremophor EL based Loratadine SEDDS were prepared. Different amount of solvent and surfactant were used to prepare SEDDS. After preparation of different formulations their dissolution studies were performed at 50-rpm, paddle method in which dissolution medium was maintained at 37°C (0.5°C) temperature by using Dissolution Tester USP II. Three capsules from each formulation were used in each dissolution study and the release profile of Loratadine was monitored up to one hour. For the formulation development with fixed dose Loratadine (10 mg) and varying amounts of oleic Acid and Cremophor EL were used. In the experiment major determinant is found to be surfactant concentration. In all cases it is found that higher surfactant concentration increased the drug release. Other two determinant factors are amount of Oleic acid and percent drug loading. It was observed that without Cremophor EL, drug release from the formulation was slow. The rate and extent of drug release increased from the matrices with increasing the amount of Cremophor EL in the formulation.
Md. Shozan Mondal, Md.Tauhidul Islam, Md. Sharifur Rahman, Md. Ariful Islam., Dissolution Enhancement of Loratadine by Formulating Oleic Acid and Cremophor EL Based Self Emulsifying Drug Delivery System (SEDDS). J App Pharm Sci, 2013; 3 (07): 064-067.
Year
Month
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