Research Article | Volume: 3, Issue: 2, February, 2013

Temperature Triggered In situ Gelling System for Betaxolol in Glaucoma

A. Geethalakshmia Roopa Karkib Poornima Sagib Sajal Kumar Jhac Venkatesh.D.Pb   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30227

The aim of this research is to develop thermo sensitive drug vehicles for glaucoma therapy in in-situ form to overcome the problems of poor bioavailability, naso lachrymal drainage and rapid precorneal elimination exhibited by conventional eye drops. Thermo sensitive ophthalmic drop was prepared using cold method by mixing thermo sensitive polymer pluronic F-127, viscosifying agent HPMC-E 50 LV and antiglaucoma drug (betaxolol hydrochloride). Prepared in situ gels were evaluated for physical parameters like appearance, gelation temperature, pH, drug content, rheological properties, isotonicity, sterility test, in vitro permeation and in-vivo ocular irritation study. The drug released from selected batch provides sustained release of betaxolol over 7 hours period and showed excellent ocular tolerance. The overall results of this study supports that the Pluronic/HPMC based vehicle could be used for controlled drug release that exhibits a greater potential for glaucoma therapy.

Keyword:     Glaucoma In situ gel ocular drug delivery &be


A. Geethalakshmi, RoopaKarki, Poornima Sagi, Sajal Kumar Jha, Venkatesh.D.P., Temperature Triggered In situ Gelling System for Betaxolol in Glaucoma. J App Pharm Sci. 2013; 3 (02): 153-159.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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