Research Article | Volume: 3, Issue: 2, February, 2013

Anti-ulcer activity of Bombax buonopozense P. Beauv. aqueous leaf extract (Fam: Bombacaceae)

Nwagba C. A; Ezugwu C.O; Eze C.C; Anowi F.C; Ezea S.C; Nwakile C. D.   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30224
Abstract

The objective of this study was to investigate the anti-ulcer activity of leaves of Bombax buonopozense P. Beauv. (Bombacaceae) in rats. Fresh dried leaves of B.buonopozense were extracted by cold maceration which yielded a mucilaginuous aqueous extract. Anti-ulcer effects of the aqueous extract at 100, 200 and 400 mg/kg were evaluated in rats using ethanol-induced ulcer model. Phytochemical analysis and lethality tests (LD50) were carried out using standard procedures. Results showed that the aqueous extract exhibited significant (P<0.05) and dose- dependent anti-ulcer activity in the model used. Percentage ulcer inhibitions of extract at 100, 200 and 400 mg/kg for ethanol-induced ulcers were 39.76, 62.07 and 75.73% respectively. Ulcer protection in the model used by the extract is dose-dependent and the ulcer inhibitory effects of the extract are comparable to ranitidine. Oral LD50 value is 2828.42 mg/kg in mice. Phytochemical analysis showed the presence of flavonoids, saponins, tannins, resins, balsams, carbohydrates, oligosaccharides, terpenes, reducing sugars and sterols. Therefore, results of our study suggest that the aqueous extract of B. buonopozense possesses anti-ulcer activity as claimed by its folkloric use.


Keyword:     Anti-ulcer activity B. buonopozense leaves phytochemical analysis.


Citation:

Nwagba, C. A, Ezugwu, C.O, Eze, C.C, Anowi, F.C; Ezea, S.C,Nwakile, C. D. Anti-ulcer Activity of Bombax Buonopozense P. Beauv. aqueous leaf Extract (Fam: Bombacaceae). J App Pharm Sci. 2013; 3 (02): 139-142.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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