Research Article | Volume: 3, Issue: 2, February, 2013

Significance of apoptotic markers Bcl-2, CD4+ T cells, hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV

Eman R.Youness M .El Nemr Hoda M.El Azizy and Hanan F. Aly   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30220

To examine the possible involvement of human B-cll leukemia /lymphoma 2(Bcl2) , CD 4+ cells , hepatocyte growth factor (HGF) and metalloproteinase -9 ( MMP-9), in the development of liver diseases caused by HCV infection, serum activities of these biomarkers were demonstrated by quantitave detemination of Enzyme Linked Immunosorbant Assay(ELISA) . Two groups of subjects (60 for each) were examined in this study: healthy control and patients with chronic hepatitis C(HCV) The results showed significant decrease in Bcl-2 (P≤ 0.0001) , and CD 4+ (P≤0.001) , while significant increase in HGF and MMP-9(P≤0.05). These findings imply an influence of these biomarkers by the existence of virus that might influence the following progression of liver disease, and a distinction between the pathological mechanisms of HCV. Since the serum MMP-9 activity were significantly varied between each stage of liver disease, an individual profile of these parameters might serve as an easy accessing serum marker to monitor the progression of liver disease.

Keyword:     HCV MMP-9 Bcl-2 CD 4+ and HGF.


Eman R.Youness , M .El Nemr, Hoda M.El Azizy and Hanan F. Aly., Significance of apoptotic markers Bcl-2 , CD4+ T cells , hepatocyte growth factor and metalloproteinase -9 in infected patients with HCV. J App Pharm Sci. 2013; 3 (02): 115-121.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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