Research Article | Volume: 3, Issue: 2, February, 2013

Evaluation of Hepatoprotective and antioxidant potential of methanolic extract of Polyalthiya longifolia fruits: An In-vitro and In-vivo approach

Jayaraman Rajangam A.J.M.Christina   

Open Access   

Published:  Feb 27, 2013

DOI: 10.7324/JAPS.2013.30212
Abstract

The aim of the study was to investigate the hepatoprotective and antioxidant potential of methanolic extract of Polyalthiya longifolia fruits (MEPL) by in-vitro and in-vivo methods.In the invitro study, Freshly isolated rat primary hepatocytes and HepG2 cells were exposed with CCl4 along with/without various concentrations of MEPL(125,250,500 µg/kg) and the effects were studied.In the in-vivo studies, CCl4 intoxication method was used and aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and total proteins were estimated and supported with histopathological studies. MEPL (125,250,500 µg/kg) treated animals increased the percentage of viability in both primary hepatocytes (p


Keyword:     Polyalthiyalongifolia Hepatocytes Hepataprotective antioxidant Carbon tetrachloride HepG2.


Citation:

Jayaraman Rajangam, A.J.M.Christina., Evaluation of Hepatoprotective and antioxidant potential methanolic extract of Polyalthiya longifolia fruits: An In-vitro and In-vivo approach. J App Pharm Sci. 2013; 3 (02): 069-076.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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