Short Communication | Volume: 2 Issue: 12, December, 2012

Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr

Akhmad Darmawan ,  ,  Soleh Kosela,  Leonardus B.S. Kardono,  and Yana M. Syah   
Akhmad Darmawan1 , 2, Soleh Kosela2, Leonardus B.S. Kardono1, and Yana M. Syah3

1Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Indonesia, Depok, West Java, Indonesia.

2Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten, Indonesia.

3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bandung Institutes of Technology, Bandung, West Java, Indonesia.

Open Access    DOI: 10.7324/JAPS.2012. 21231

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Abstract

Scopoletin (1), a coumarin derivative compound has been isolated from methanol extract of Macaranga gigantifolia Merr. leaves using chromatography methods. Chemical structure determination carried out based on spectroscopic data and compared with a reference. Scopoletin cytotoxicity test using MTT assay method against P-388 murine leukemia cells showed strong cytotoxic activity with IC50 17.42 μg/mL.


Keyword:     Scopoletin Coumarin Derivative Macaranga Gigantifolia Merr.

Citation:

Akhmad Darmawan, Soleh Kosela, Leonardus B.S. Kardono, and Yana M. Syah., Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr. J App Pharm Sci. 2012; 2 (12): 175-177.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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