Research Article | Volume: 3, Issue: 1, January, 2013
Research Article | Volume: 3, Issue: 1, January, 2013
The Haematological studies of garlic, antioxidant vitamins C and E on pefloxacin-induced toxicity in wistar rat was evaluated. Method: One hundred adult wistar rats (120-180), of either sex were randomly selected into five study groups. Each group comprised of 10 pairs (ten males and ten females) were not allowed to mate, with group 1 as control. Group 11 were pefloxacin treated only while group 111 to 1V were pefloxacin treated with either garlic, vitamins C and E. Pefloxacin, garlic vitamin C and E in doses 11.43mg/kg, 4.28mg/kg, 14.29mg/kg body weight in normal saline (vehicle) was administered orally by intubation to both male and female of groups 11 to V for 14 days. Control animals received 0.5ml of normal saline. In life observation measurements were taken and at the end of drug, garlic, antioxidant vitamins C and E combined administration animals were sacrificed and tissues obtained for biochemical assessment. Result: Physical signs of toxicity and ameliorating effects of antioxidant vitamins and garlic were also expressed in rats, significant (p<0.05) decrease in Hb, PCV, RBC and Total WBC were observed. Conclusion: These results suggest adverse effect of pefloxacin and ameliorating role of garlic, vitamins C and E on wistar rats.
Ukpanukpong, R. U, Eteng, M. U and Pekene, D. B. J., Haematological studies of antioxidant vitamins C, E and garlic on Pefloxacin Induced Toxicity in Wistar Rats. J App Pharm Sci. 2013; 3 (01): 103-107.
Year
Month
The Pharmacokinetic and Biopharmaceutical Effect of Ascorbic acid (Vitamin C) on Pefloxacinon Concurrent Administration in Human
The effect of ginger and garlic on the microbial load and shelf life of Kunun-zaki
Edward, K.C., Ohaegbu, C.G.Antioxidant interactions of Pefloxacin, garlic, vitamins C and E on lipid profile level of Albino wistar rats
Effect of Trigonella Foenum-Graecum seed powder on anthropometrical and nutritional parameter