Research Article | Volume: 2 Issue: 12, December, 2012

Mucoadhesive Polymeric Hydrogels for Nasal Delivery of Penciclovir

Arindam Das Prof. B. K. Gupta Bhole Nath   

Open Access    DOI: 10.7324/JAPS.2012.21228

Abstract

The study evaluated different mucoadhesive polymeric hydrogels for nasal delivery of penciclovir . Gels containing poly-N-vinyl-2-pyrrolidone (PVP) were prepared with crosslinking achieved by irradiation with a radiation dose of 15 kGy being as efficient as 20 kGy. Gels containing chitosan and carbopol were also evaluated. The mucoadhesive properties of gels were measured by a modification of a classical tensile experiment, employing a tensile tester and using freshly excised sheep nasal mucosa. Considering the mucoadhesive force, chitosan gel and gel prepared with 3% PVP in presence of polyethylene glycol (PEG) 600 were the most efficient. The in vitro drug release depended on the gel composition. Higher release rates were obtained from PVP gels compared to chitosan or carbopol gels. The release rate of drug from PVP gels was increased further in presence of PEG or glycerol. Histopathological investigations proved that the PVP was a safe hydrogel to be used for mucosal delivery. The PEG in gel formulations caused less damages to the nasal mucosal compared to formulation containing glycerol.


Keyword:     Penciclovir nasal nasal mucoadhesion poly-N-vinyl-2- pyrrolidone hydrogels chitosan nasal carbopol nasal.


Citation:

Arindam Das, Prof. B. K. Gupta, Bhole Nath., Mucoadhesive Polymeric Hydrogels for Nasal Delivery of Penciclovir . J App Pharm Sci. 2012; 2 (12):158-166.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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