Research Article | Volume: 2 Issue: 11, November, 2012

Design and Characterization of Oral Dispersible Tablets of Enalapril Maleate Using a Co-Processed Excipient

Swamy NGNSachin and Abbas Z   

Open Access    DOI: 10.7324/JAPS.2012.21108


In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate were prepared by employing direct compression technique using the above superdisintegrants, and evaluated for precompression as well as post-compression parameters, such as determination of weight variation, thickness, hardness, friability, wetting time, disintegration time, drug content, water absorption ratio, in vitro dispersion time, and in vitro drug release study. Formulation F-VII. F-VIII and F-IX were subjected to stability Studies as per ICH guidelines at temperatures and humidity of 25±5ºC/60±5%RH; 30±5ºC/65±5%RH and 40±5ºC/75±5%RH. Tablets didn't reveal any appreciable changes in respect to hardness, disintegration time, drug content and dissolution profiles. From the results, it could be concluded that the formulation(F-VII) made with co-processed super disintegrant (1:1) at a concentration of 5% w/w revealing a disintegrating time of 13.2 sec, and 97.84 % cumulative drug release emerged as the best formulation.

Keyword:     Enalapril maleateco-processed superdisintegrantin vitro dispersiondisintegration time.


Swamy Ngn, Sachin, Abbas , Design and Characterization of oral Dispersible Tablets of Enalapril Maleate Using A Co-Processed Excipient. J App Pharm Sci. 2012; 2 (11): 040-049.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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