Research Article | Volume: 2 Issue: 8, August 2012

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Lucky Lebgosi Nwidu,  Paul Alozie Nwafor,  Wagner Vilegas   
Lucky Lebgosi Nwidu1, Paul Alozie Nwafor2, Wagner Vilegas3

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria; P.O. Box 10935, Port Harcourt Nigeria.

2Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom State, 520003, Nigeria.

3Department of Organic Chemistry, Chemistry Institute, São Paulo State University, UNESP-CP 355, CEP 14801-970, Araraquara, SP, Brazil.

Open Access    DOI: 10.7324/JAPS.2012.2841

PDF [ 0.3 MB]
Request Permission
Share
Download Citation
Print
Download PDF
Abstract

Carpolobia lutea leaves (CLL) (Polygalaceae) were earlier screened and the antiulcer ethnomedicinal claim established. This article seeks to quantitatively isolate, elucidate the active compounds from most active CLL fraction. Fractionation was by semi-preparative HPLC; the active fraction was subjected to radical scavenging assays (RSA) and quantification of the total phenolic content (TPC) were also executed. Results: Ethyl acetate fraction (EAF) was observed to be the most pharmacologically active antiulcer fraction when screened using acute ulcer models induced in rodents. The EAF demonstrated significant (p


Keyword:     Carpolobia luteaPolygalaceae cinnamoyl-coumaroyl- 1-deoxyglucoside ulcerogenic.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HTML Full Text

Reference

Article Metrics
374 Views 10 Downloads 384 Total

Year

Month

Related Search

By author names