Research Article | Volume: 2 Issue: 8, August 2012

Antiulcer Effects of Ethyl acetate Fraction of Carpolobia lutea Leaf

Lucky Lebgosi Nwidu Paul Alozie Nwafor Wagner Vilegas   

Open Access    DOI: 10.7324/JAPS.2012.2841

Abstract

Carpolobia lutea leaves (CLL) (Polygalaceae) were earlier screened and the antiulcer ethnomedicinal claim established. This article seeks to quantitatively isolate, elucidate the active compounds from most active CLL fraction. Fractionation was by semi-preparative HPLC; the active fraction was subjected to radical scavenging assays (RSA) and quantification of the total phenolic content (TPC) were also executed. Results: Ethyl acetate fraction (EAF) was observed to be the most pharmacologically active antiulcer fraction when screened using acute ulcer models induced in rodents. The EAF demonstrated significant (p


Keyword:     Carpolobia luteaPolygalaceae cinnamoyl-coumaroyl- 1-deoxyglucoside ulcerogenic.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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