Research Article | Volume: 2 Issue: 9, September, 2012

Development, Evaluation and Stability Studies of Zidovudine and Lamivudine (ZILA) Tablet Dosage Form

Vikramjit Singh Nawazish Alam Monika Sharma Md. Sarfaraz Alam Md. Sajid Ali Md. Intakhab Alam   

Open Access    DOI: 10.7324/JAPS.2012.2929

Abstract

Tablets containing zidovudine and lamivudine (ZILA) were prepared by direct compression method. Optimization studies were done for the selection of glidant, lubricant and coating materials. Evaluation of granuleswere done on the basis of preformulation studies. The prepared tablets were evaluated for physicochemical properties. The in- vitro release studies were performed as per USP and compared with marketed product. The release of zidovudine and lamivudine were analysed by high performance liquid chromatography (HPLC). The ZILA tablets exhibited better release characteristics than the marketed product. Stabilities studies were performed in both blister as well as cold form blister packings. Stabilities studies revealed the suitability of blister package in comparison to the cold form blister packing. From the study it was concluded that the selected composition can be used for the preparation of tablets that can be used for the treatment of HIV-1 and Hepatitis-B after performing studies on animals for its suitability and efficacy.


Keyword:     ZidovudineLamivudineHIVDirect compressionBlister packing.


Citation:

Vikramjit Sing, Nawazish Alam, Monika Sharma, Md. Sarfaraz Alam2 , Md. Sajid Ali, Md. Intakhab Alam Development, Evaluation and Stability Studies of Zidovudine and. J App Pharm Sci. 2012; 2(9): 149-154.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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