Open Access DOI: 10.7324/JAPS.2012.2929
Tablets containing zidovudine and lamivudine (ZILA) were prepared by direct compression method. Optimization studies were done for the selection of glidant, lubricant and coating materials. Evaluation of granuleswere done on the basis of preformulation studies. The prepared tablets were evaluated for physicochemical properties. The in- vitro release studies were performed as per USP and compared with marketed product. The release of zidovudine and lamivudine were analysed by high performance liquid chromatography (HPLC). The ZILA tablets exhibited better release characteristics than the marketed product. Stabilities studies were performed in both blister as well as cold form blister packings. Stabilities studies revealed the suitability of blister package in comparison to the cold form blister packing. From the study it was concluded that the selected composition can be used for the preparation of tablets that can be used for the treatment of HIV-1 and Hepatitis-B after performing studies on animals for its suitability and efficacy.
Vikramjit Sing, Nawazish Alam, Monika Sharma, Md. Sarfaraz Alam2 , Md. Sajid Ali, Md. Intakhab Alam Development, Evaluation and Stability Studies of Zidovudine and. J App Pharm Sci. 2012; 2(9): 149-154.
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