Research Article | Volume: 2 Issue: 9, September, 2012

Antispasmodic Effects of Aqueous extract of Anthemis mauritiana Maire & Sennen Flowers

Mohammed AZIZ Ahmed KARIM Hassane MEKHFI Mohamed BNOUHAM Abderrahim ZIYYAT Abdelkhaleq LEGSSYER Ahmed MELHAOU   

Open Access    DOI: 10.7324/JAPS.2012.2908


The effects of aqueous extract of Anthemis mauritiana Maire & Sennen flowers (AM) on rabbit and rat jejunum were studied. The AM (0.1-3 mg/mL) showed reversibly relaxation of spontaneous contractions on isolated rabbit jejunal smooth muscle The spasmolytic effect was dose-dependent with IC50 value of 1,48 ± 0,02 mg/ml. Similarly this extract inhibited the contractions of rat jejunum induced by KCl (75mM) and Carbachol (CCh, 10-6M) with IC50 values of 0,48 ± 0,09 mg/ml and 1,53 ± 0,03 mg/ml respectively. Furthermore, AM exhibited an inhibitory effect on the dose-response curves induced by CCh and CaCl2 on rat jejunum. These results clearly demonstrated the antispasmodic effect of AM which was strongly suggested to be mainly due to the inhibitory effect on Ca++ influx through membrane of jejunal smooth muscle.

Keyword:     Anthemis mauritiana Maire & Sennen jejunum rodent antispasmodic.


Mohammed Aziz, Ahmed Karim, Hassane Mekhfi, Mohammed Bnouham, Abderrahim Ziyyat, Abdelkhaleq Legssyer & Ahmed Melhaoui. Antispasmodic Effects of Aqueous extract of Anthemis mauritiana Maire & Sennen Flowers. J App Pharm Sci. 2012; 2(9): 041-044.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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