Research Article | Volume: 2 Issue: 8, August 2012

Antioxidant and Hepatoprotective Effects of Dried Flower Extracts of Hibiscus sabdariffa L. on Rats Treated with Carbon Tetrachloride

Itoro F Usoh,  Itemobong S Ekaidem,  Oboso E Etim,  Henry D Akpan,  Enomfon J Akpan,  A Fakoya   
Itoro F Usoh1, Itemobong S Ekaidem2, Oboso E Etim1, Henry D Akpan1, Enomfon J Akpan1, A Fakoya3

1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo- Nigeria.

2Department of Chemical Pathology, Faculty of Clinical Sciences, University of Uyo-Nigeria.

3Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan-Nigeria.

Open Access    DOI: 10.7324/JAPS.2012.2832

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Abstract

The hypolipidemic, antioxidative and hepatoprotective activities of 200 and 300mg/kg body weight ethanolic extract of dried flower of Hibiscus sabdariffa L. (HSE) were assessed in rats treated with 0.25ml/kg body weight (intraperitoneally) of carbon tetrachloride (CCl4). Hepatic malondialdehyde (MDA), serum lipid profile, serum vitamins A, C and β-carotene, alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities were measured. The oral administration of the extracts showed a significant (P


Keyword:     Carbon tetrachlorideHibiscus sabdariffa Lantioxidant activityhepatoprotective activityhypolipidemic activity.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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