Research Article | Volume: 2 Issue: 7, July 2012

Phytochemical and Anticonvulsant Studies on the Aqueous Ethanol Extract of the Root-Back of Ficus Abutilifolia (Miq.) Miq. (Family: Moracea)

U. H. Danmalam P. K. Allahmagani N. Ilyas E. M. Abdurahman A. H. Yaro M. G. Magaji   

Open Access    DOI: 10.7324/JAPS.2012.2739


Ficus abutilifolia, belonging to the family Moraceae is a small to medium sized tree that grow mostly in the African continent. It was reported to be used traditionally, in promoting fertility in humans and in the treatment of skin wart and management of epilepsy. Preliminary phytochemical investigation of the powdered root revealed the presences of flavonoids, saponins and tannins among others. The intra-peritoneal LD50 of the 70% aqueous ethanol extract was found to be 2154.1 mg/Kg in mice. The anticonvulsant studies of the extract revealed that a single administration (at the dose of 100 – 400 mg/Kg) produced a dose-dependent protection against MEST; however, the extract did not offer significant protection against pentylenetetrazole- and 4-amino pyridine–induced seizures. These finding suggest some level of protection by the aqueous ethanol extract against MES induced seizure in chicks, thereby giving support to the traditional claim for the use of the plant in the treatment and/or management of convulsion and epilepsy.

Keyword:     Anticonvulsant plantsFicus abutilifolia Ethanol extract Phytochemical screening.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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