Research Article | Volume: 2 Issue: 7, July 2012

Formulation and Evaluation of Sustained Release Ondansetron Poloxamer Based Solid Suppositories

Zawar L R Bhandari G S   

Open Access    DOI: 10.7324/JAPS.2012.2729

Abstract

The present investigation studies the effect of water swellable polymer hydroxylpropylmethyl cellulose (HPMC K4M, Methocel) on in vitro release of ondansetron from suppositories. Suppositories were prepared by using mixture of Poloxamer 407 and Poloxamer 188 hydrophilic bases. Suppositories containing 16 mg of ondansetron were prepared by fusion method. Weight variation, content uniformity, breaking (hardness), disintegration time, melting point and liquefaction time of the formulations were determined. In vitro release test was carried out according to USP XXII basket method. In vitro release data demonstrates ondansetron release from suppositories up to 12hrs and follows the zero order kinetics from poloxamer mixture based suppositories.


Keyword:     Ondansetron Poloxamer 407 poloxamer 188 HPMC sustain release.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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