Research Article | Volume: 2 Issue: 7, July 2012

Dry Suspension Formulation of Taste Masked Antibiotic Drug for Pediatric Use

Harshada Sanjay Akre Dharmendra R. Mundhada Shyamala Bhaskaran Sohail Asghar Gopal Satishkumar Gandhi   

Open Access    DOI: 10.7324/JAPS.2012.2725

Abstract

Dry suspension is commercial dry mixtures that require addition of water at the time of dispensing. The major consequence of the bitter taste is to restrict greatly the further development of oral preparations and clinical applications of these drugs. People wish to take effective drugs that have a nice taste can be administered easily. Accordingly, it is important to mask the unpalatable taste of a drug in order to improve the product quality. The solvent evaporation process is used for microencapsulation which is carried out in a liquid manufacturing vehicle. Eudragit L100 is used as taste masking agent. FT-IR study shows that there is no significant interaction occurring between drug and excipients. The suspension prepared was evaluated for various parameters like sedimentation volume, degree of flocculation, drug content and In-vitro dissolution time. All the parameters were found to be within limits. When the results were compared with marketed preparation suspension was found to be better with respect to marketed preparation.


Keyword:     Dry suspension Taste Masking Macrolide Antibiotic Eudragit L 100.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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