Research Article | Volume: 2 Issue: 7, July 2012

Hemostatic potential of the sap of Musa sapientum L. (Musaceae)

Klotoe JR,  Dougnon TV,  Sacramento TI,  Dandjesso C,  Edorh AP,  Koudokpon H,  Fanou VBA,  Fah L,  Ategbo JM,  Loko F,  Dramane K.   
Klotoe JR1, Dougnon TV1, Sacramento TI2, Dandjesso C1, Edorh AP3, Koudokpon H1, Fanou VBA1, Fah L, Ategbo JM2, Loko F1, Dramane K.2

1Ecole Polytechnique d’Abomey-Calavi (EPAC), Département de Biologie Humaine, Laboratoire de Recherche en Biologie Appliquée (LARBA), Université d’Abomey-Calavi (UAC), 01 BP 2009 Cotonou, Bénin.

2Faculté des Sciences et Techniques (FAST), Département de Physiologie animale, Laboratoire de Pharmacologie, Université d’AbomeyCalavi (UAC), 01 BP 526 Cotonou, Bénin.

3Faculté des Sciences et Techniques (FAST), Département de Biochimie et Biologie Cellulaire, Université d’Abomey-Calavi, (UAC), 01 BP 526 Cotonou, Bénin.

Open Access    DOI: 10.7324/JAPS.2012.2707

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Abstract

In Benin, Musa sapientum is one of the most important medicinal species used in the treatment of bleeding. In this study, hemostatic properties of M. sapientium sapand its mechanism of action have been identified through hematologic tests such as Clotting Time, Prothrombin Time, Activated Partial Thromboplastin Time and Milk Precipitation Test; biochemical test (total proteins); macroscopic and microscopic tests performed on different blood products before and after addition of sap. The results obtained showed that Musa sapientum reduced significantly clotting Time. However, it has no effect on the individual factors of coagulation. Its mechanism of action results from its ability to form a protein network which is a basis for cellular aggregation stopping bleeding. Moreover, Milk Precipitation Test showed astringent properties of Musa sapientum and therefore its vasoconstrictors properties. Phytochemical analyses revealed the presence of alkaloids, tannins, coumarins, reducing compounds, anthocyanins and leucoantocyanes. M. sapientum is great on treatment of bleeding and could help to elaborate new drugs.


Keyword:     Musa sapientumcoagulationhemostaticprotein network.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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