Review Article | Volume: 2 Issue: 7, July 2012

In-vivo and in-vitro screening of medicinal plants for their anti-inflammatory activity: an overview

Mohini A. Phanse Manohar J. Patil Konde Abbulu Pravin D. Chaudhari Bhoomi Patel   

Open Access    DOI: 10.7324/JAPS.2012.2704


Despite the progress made in medical research for the past decades, the treatment of many serious diseases is still problematic. Inflammation is the response of living tissues to injury. It involves a complex array of enzyme activation, mediator release, extravasations of fluid, cell migration, tissue breakdown and repair. Inflammation has become the focus of global scientific research because of its implication in virtually all human and animal diseases. As a result of adverse effects such as gastric lesions caused by non-steroidal anti-inflammatory drugs (NSAID), tolerance and dependence induced by opiates, the use of these drugs as anti-inflammatory agents have not been successful in all cases. Therefore, new anti-inflammatory drugs lacking these side effects are being researched as alternatives to NSAID and opiates. Attention is being focused on the investigation of the efficacy of plant-based drugs used in the traditional medicine because they are cheap, have little side effects. Hence, in the present review the various animal models used for preclinical screening anti-inflammatory activity herbs was compiled.

Keyword:     Inflammation Animal Models Plant Extract Mechanism of action.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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