Research Article | Volume : 2 Issue : 6, June 2012

Antimicrobial, cytotoxic and thrombolytic activityof Cassia senna leaves (family: Fabaceae)

Md. Kamal Hossain Md. Musfizur Hassan Most. Nazma Parvin Md. Mahmudul Hasan Md. Siddiqul Islam Md. Ahsanul Haque   

Open Access    DOI: 10.7324/JAPS.2012.2607

Abstract

Cassia senna leaves belonging to the family Fabaceae have been investigated for the presence of its secondary metabolites and evaluation of biological activities of the crude extracts with special emphasis to the antimicrobial activity, cytotoxic activity and thrombolytic activity. The antimicrobial activities of n-hexane, chloroform, ethyl acetate & methanolic extracts of C. senna leaves were screened against five gram (+) bacteria, eight gram (-) bacteria and three fungi by 'disc diffusion method'. The methanol extract possesses no antimicrobial activity but chloroform and n-hexane fractions exhibited moderate to less activity against some organisms tested compared with the standard antibiotic Kanamycin. Brine shrimp lethality bio-assay wasdone using brine shrimp Nauplii and dimethyl sulfoxide as a solvent for the methanol extracts ofC. senna. The LC50 value (1.5625) of methanol extract of the plant indicated that thecytotoxicity was very significant. The percentages found in thrombolytic tests are 41.46%,53.22%, 33.33%, 4.08% and standard 92.85%. So, in comparison with standard, C. senna can befurther use as mild thrombolytic agent.


Keyword:     Cassia sennaantimicrobial activitycytotoxic activitythrombolytic activitykanamycindimethyl sulfoxide.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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