Research Article | Volume : 2 Issue : 6, June 2012
Antimicrobial, cytotoxic and thrombolytic activityof Cassia senna leaves (family: Fabaceae)
Open Access DOI: 10.7324/JAPS.2012.2607
Research Article | Volume : 2 Issue : 6, June 2012
Open Access DOI: 10.7324/JAPS.2012.2607
Cassia senna leaves belonging to the family Fabaceae have been investigated for the presence of its secondary metabolites and evaluation of biological activities of the crude extracts with special emphasis to the antimicrobial activity, cytotoxic activity and thrombolytic activity. The antimicrobial activities of n-hexane, chloroform, ethyl acetate & methanolic extracts of C. senna leaves were screened against five gram (+) bacteria, eight gram (-) bacteria and three fungi by 'disc diffusion method'. The methanol extract possesses no antimicrobial activity but chloroform and n-hexane fractions exhibited moderate to less activity against some organisms tested compared with the standard antibiotic Kanamycin. Brine shrimp lethality bio-assay wasdone using brine shrimp Nauplii and dimethyl sulfoxide as a solvent for the methanol extracts ofC. senna. The LC50 value (1.5625) of methanol extract of the plant indicated that thecytotoxicity was very significant. The percentages found in thrombolytic tests are 41.46%,53.22%, 33.33%, 4.08% and standard 92.85%. So, in comparison with standard, C. senna can befurther use as mild thrombolytic agent.
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