Research Article | Volume : 2 Issue : 6, June 2012

Management of Changes in Liver Chemistry in Male Rats Acutely Exposed to Crude Petroleum Oil

C.O. Ujowundu,  F.N. Kalu,  L.A. Nwaogu,  E.U. Ezeji,  K.O. Igwe   
C.O. Ujowundu1, F.N. Kalu2, L.A. Nwaogu1, E.U. Ezeji1, K.O. Igwe1

1Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.

2Department of Biochemistry, University of Nigeria, Nsukka, Nigeria

Open Access    DOI: 10.7324/JAPS.2012.2604

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Abstract

This Study investigated the protective effect of Gongronema latifolium supplemented diet against acute hepatotoxicity induced by crude petroleum oil on male rats. Oral exposure of rats to crude petroleum significantly decreased (P<0.05) the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD). Significant decrease in concentrations of glutathione and increase in malondialdehyde (MDA) was observed also, but catalase activity decreased non-significantly. Activities of these oxidative stress enzymes and concentrations of glutathione and MDA in rats exposed to crude petroleum and fed simultaneously with 20% G. latifolium supplemented diet were close to those obtained in control rats. Fluctuations in liver function parameters and serum lipid profile were observed. These results indicate that consumption of G. latifolium supplemented diet has protective effect against crude oil induced liver tissue damage.


Keyword:     Hepatotoxicityoxidative enzymescrude oilliver function enzymesGongronemalatifolium.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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