Research Article | Volume : 2 Issue : 5, May 2012

Withaferin A targets apoptosis inhibitor cIAP1: A potential anticancer candidate

V.P. Wadegaonkar P.A. Wadegaonkar   

Open Access    DOI: 10.7324/JAPS.2012.2527

Abstract

Inhibitors of Apoptosis (IAPs) are important and well studied molecules in the cancer pathway. These are known inhibitors of apoptosis and are over expressed in many tumours where they confer chemo-resistance. The cIAP1 inhibits caspase 3 and caspase 7 and ensures suppression of apoptosis. Docking studies carried out with herbal ligand withaferin A derived from roots of Withania somnifera onto the structure of cIAP1. Withaferin A has shown strong binding affinity of -15.4988 kJ/mol with BIR domain of cIAP1 and in turn interfere in the binding of cIAP1 molecule to caspase 3 and caspase 7 and thus result into prevention of inhibition of these effecter proteins. The docking studies support the experimental outcomes and suggest that withaferin A has potential to develop as candidate molecule for cancer therapy.


Keyword:     Apoptosis Inhibitors of apoptosis Withania somnifera.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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