Research Article | Volume : 2 Issue : 4, April 2012
Open Access DOI: 10.7324/JAPS.2012.2419
Administration of dietary antioxidants has been suggested to protect against the subsequent liver tissue damage. The present data to explore the hepatoprotective and antioxidant effect of anserine nitrate and /or zinc chloride against γ-irradiation induced hepatotoxicity. Healthy male albino rats were exposed to γ-irradiation from Co60 gamma cell 3500 at dose level (5.7 Gy) at a dose rate 2.67 rad/sec after 24 h and 14 days on the liver and to determine both prophylactic and therapeutic role of intraperitoneally administrated. Exposure to γ- irradiation induced a significant increase in levels of ALP, ALT and AST, while levels of glucose, total proteins, albumin, triglycerides, cholesterol, LDL-C, HDL-C, total, direct and indirect bilirubin and serum fractions were significantly decreased except for total lipids level which was almost not affected. Administration of anserine and/or zinc prior or after radiation exposure was found to offer protection against γ-irradiation induced hepatocellular damage and oxidative stress in rats, probably by exerting a protective effect against hepatocellular necrosis via its free radical scavenging and membrane stabilizing ability.
Year
Month
Productivity of L-DOPA in in vitro shoots of Mucuna pruriens var. utilis enhanced by gamma radiation
Detmontree Wachisunthon, Sorrapetch Marsud, Subhadhcha Poonsatha, Suwimol Jetawattana, Worapan SitthithawornInteraction of Ketoconazole with Bovine Serum Albumin: Electrochemical, Spectroscopic and Molecular Modeling Studies
In-vitro interaction of verapamil hydrochloride with magnesium sulphate (anhydrous) and its influence on protein binding of verapamil hydrochloride
Joysree Das, Irfan Newaz Khan, Fouzia Siraji, Syeda Ridita Sharif, Marzina AjrinSoluble Curcumin: A Promising Oral Supplement For Health Management
Puneet Gandhi, Zeba Khan, Nivedita ChakravertyAntioxidant enzyme activity and lipid peroxidation in rat liver exposed to celecoxib and lansoprazole under epinephrine-induced stress