Production and biological properties of nano porous glass microparticles for anticancer drug carrier

Emre Burak Ertus Elif Gulbahce-Mutlu Serife Alpa Abdullah Ozturk   

Open Access   

Published:  Jun 14, 2024

DOI: 10.7324/JAPS.2024.168308
Abstract

Nanoporous glass (NPG) microparticles were produced by conventional melt-quenching followed by acid-alkali leaching to get material for anticancer drug carriers. NPG exhibited a positive zeta potential of 34 mV after [3-(2-aminoethylamino) propyl] trimethoxysilane treatment. The specific surface area and the total pore volume of NPG were 47.3 m2/g and 0.692 cm3/g, respectively. The 5-Fluorouracil (5FU) loading capacity of NPG was measured as 18.2 ± 0.2 mg5FU/gNPG. The drug release rate was monitored for 120 hours. To evaluate the cytotoxic effects of NPG on both MCF-7 breast cancer cells and MCF-12A, an immortalized cell line, the study employed the 2,3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium5-carboxanilide inner salt (XTT) assay. The XTT results revealed that NPG showed a time and concentration-dependent cytotoxic effect. It is anticipated that NPG is a safe and effective material for drug delivery systems for in vitro and a promising alternative material for in vivo applications.


Keyword:     Porous glass 5FU MCF7 drug release breast cancer


Citation:

Ertus EB, Gulbahce-Mutlu E, Alpa S, Ozturk A. Production and biological properties of nano porous glass microparticles for anticancer drug carrier. J Appl Pharm Sci. 2024. Online First. http://doi.org/10.7324/JAPS.2024.168308

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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