Evaluation of treatment effectiveness and 10-year cardiovascular disease risk level in hypertensive outpatients

Aliyu Samaila Umar Idris Ibrahim Aminu Ahmed Biambo Bilkisu Muhammad Tambuwal   

Open Access   

Published:  May 15, 2024

DOI: 10.7324/JAPS.2024.171162
Abstract

Hypertension represents a substantial risk factor for the development of cardiovascular disease (CVD), stroke, and chronic kidney disease. CVD stands as the primary cause of global mortality. This study employed a prospective cross-sectional design spanning 4 weeks. Data were collected using a pro forma designed to capture patients’ sociodemographic and clinical information. Prescribers’ adherence to anti-hypertensive prescription guidelines, as per the JNC8 guideline, and patients’ attainment of target blood pressure (BP) goals were assessed. Framingham 10-year CVD risk score estimation was employed to estimate patients’ 10-year CVD risk levels. Among the patients, 51 (59.3%) had anti-hypertensive prescriptions that adhered to the JNC8 guidelines. However, a majority, 54 (62.8%), failed to achieve their JNC8 target BP goals, and 44 (51.2%) exhibited intermediate 10-year CVD risk levels. Furthermore, 71 (98.6%) of the patients did not receive the recommended statin and/or aspirin therapy, despite its necessity. An association was found between patients’ achievement of JNC8 target BP goals and their 10-year CVD risk levels. The majority of patients received anti-hypertensive prescriptions that aligned with JNC8 guidelines. Nonetheless, most of them did not attain their JNC8 target BP goals and exhibited intermediate to high 10-year CVD risk levels.


Keyword:     Hypertension treatment effectiveness cardiovascular disease risk


Citation:

Samaila A, Ibrahim UI, Biambo AA, Tambuwal BM. Evaluation of treatment effectiveness and 10-year cardiovascular disease risk level in hypertensive out- patients. J Appl Pharm Sci. 2024. Online First. http://doi.org/10.7324/JAPS.2024.171162

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation. 2013;127:e6-245.

2. Shahwan AJ. Epidemiology of cardiovascular disease and associated risk factors in Gaza Strip-Palestine [Doctoral Dissertation]. Limoges, France: Université de Limoges.

3. Yasui D, Asayama K, Ohkubo T, Kikuya M, Kanno A, Hara A, et al. Stroke risk in treated hypertension based on home blood pressure: the Ohasama study. Am J Hypertens. 2010 May 1;23(5):508-14. https://doi.org/10.1038/ajh.2010.15

4. Lawes CM, Bennett DA, Feigin VL, Rodgers A. Blood pressure and stroke: an overview of published reviews. Stroke. 2004 Mar 1;35(3):776-85. https://doi.org/10.1161/01.STR.0000116869.64771.5A

5. Abel N, Contino K, Jain N, Grewal N, Grand E, Hagans I, et al. Eighth joint national committee (JNC-8) guidelines and the outpatient management of hypertension in the African-American population. N Am J Med Sci. 2015 Oct;7(10):438. https://doi.org/10.4103/1947-2714.168669

6. Samaila A, Biambo AA, Usman N, Aliyu HH. Drug related problems and implications for pharmaceutical care interventions in hypertensive outpatients in a Nigerian hospital. J Sci Pract Pharm. 2019;5(2):281-6. https://doi.org/10.47227/jsppharm.v5i2.7

7. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014 Feb 5;311(5):507-20. https://doi.org/10.1001/jama.2013.284427

8. Shedul GJ, Eraga SO, Odili VU, Ojji DB. Adherence to international guidelines in antihypertensive prescriptions among National Health Insurance Enrollees in a Tertiary Hospital Located in Abuja, Nigeria. Indian J Pharm Pract. 2023;16(1):46-51. https://doi.org/10.5530/097483261422

9. Anderson TJ, Grégoire J, Hegele RA, Couture P, Mancini GJ, McPherson R, et al. 2012 update of the Canadian cardiovascular society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol. 2013 Feb 1;29(2):151-67. https://doi.org/10.1016/j.cjca.2012.11.032

10. Njoku CH, Aduloju AB. Stroke in Sokoto, Nigeria: a five year retrospective study. Ann Afr Med. 2004 Nov 16;3(2):73-6.

11. Adisa R, Ilesanmi OA, Fakeye TO. Treatment adherence and blood pressure outcome among hypertensive out-patients in two tertiary hospitals in Sokoto, Northwestern Nigeria. BMC Cardiovasc Disord. 2018 Dec;18(1):1-0. https://doi.org/10.1186/s12872-018-0934-x

12. Odili VU, Oghagbon EK, Ugwa NA, Ochei UM, Agghomo OE. Adherence to international guidelines int eh management of hypertension in a tertiary Hospital in Nigeria. Trop J Pharm Res. 2008;7:945-52. https://doi.org/10.4314/tjpr.v7i2.14608

13. Sessoms J, Reid K, Williams I, Hinton I. Provider adherence to the national guideline for managing hypertension in African Americans. Int J Hypertens. 2015;2015:7. https://doi.org/10.1155/2015/498074

14. Ahmad N, Hassan Y, Tangiisuran B, Meng OL, Abd Aziz N, Ahmad FU, et al. Guideline adherence and hypertension control at a tertiary hospital in Malayia. J Eval Clin Pract. 2013;19:798-804. https://doi.org/10.1111/j.1365-2753.2012.01852.x

15. Heneghan C, Perera R, Mant D, Glasziou P. Hypertension guideline recommendations in general practice: awareness, agreement, adoption, and adherence. Br J Gen Pract. 2008;57:948-52. https://doi.org/10.3399/096016407782604965

16. Ale OK, Braimoh RW. Awareness of hypertension guidelines and the diagnosis and evaluation of hypertension by primary care physicians in Nigeria. Cardiovasc J Afr. 2017;28:72-6. https://doi.org/10.5830/CVJA-2016-048

17. Cederholm J, Nilsson PM, Anderberg CP, Fröberg L, Petersson U. Blood pressure and other cardiovascular risk factors among treated hypertensives in Swedish primary health care. Scand J Prim Health Care. 2002 Jan 1;20(4):224-9. https://doi.org/10.1080/028134302321004881

Article Metrics
17 Views 2 Downloads 19 Total

Year

Month

Related Search

By author names