The potential effects of isoflavones on nuclear receptor modulation in bone remodeling: A review

Haryati Ahmad Hairi Nor Hidayah Mustafa Putri Ayu Jayusman Ahmad Nazrun Shuid   

Open Access   

Published:  Feb 25, 2023

DOI: 10.7324/JAPS.2023.126975

Isoflavones are plant-based compounds that act as phytoestrogens by mimicking the action of estrogen. Osteoblasts and osteoclasts are the key cells for bone remodeling, a process that includes bone proliferation, differentiation, deposition, and resorption. Studies have demonstrated that isoflavones, a class of flavonoids found almost exclusively in soybeans, could prevent bone loss. Recent findings revealed that isoflavones could activate nuclear receptors (NRs) and regulate bone formation and resorption processes. This current research discussed the principal actions of isoflavones mediated by NRs on bone remodeling such as steroid receptors (estrogen receptor, estrogen-related receptor, and androgen receptor) and metabolic receptors including peroxisome proliferator-activated receptor-γ. Isoflavones modulate osteogenesis by fine-tuning physiological responses on NR sensors and their transcriptional networks. Hence, this present review will dive deep into the use of several isoflavones as potential osteoporosis treatment through NR-controlling gene regulation.

Keyword:      Isoflavones nuclear receptor bone remodeling bone formation bone resorption


Hairi HA, Mustafa NH, Jayusman PA, Shuid AN. The potential effects of isoflavones on nuclear receptor modulation in bone remodeling: A review. J Appl Pharm Sci, 2023.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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