Neonatal outcomes associated with antimicrobial resistance: A retrospective cross-sectional study

Prashant Chandra Faiza Iqbal Mazhuvancherry Kesavan Unnikrisnan Purkayastha Jayashree Padmaja A. Shenoy Stanly Elstin Anburaj Vilakkathala Rajesh Mallayasamy Surulivelrajan Leslie Edward Lewis   

Open Access   

Published:  Jan 17, 2023

DOI: 10.7324/JAPS.2023.120166

Neonatal sepsis (NS) is a leading cause of morbidity and mortality requiring immediate admission and prolonged neonatal intensive care unit (NICU) stay. This study attempts to identify factors associated with NS and its outcomes. A total of 186 NS case records (January 2017 to September 2019) were analyzed retrospectively. Multiple logistic regression and linear regression were employed to determine the factors associated with mortality, length of NICU stay, and treatment cost with a significance level of p ≤ 0.05. The mean neonatal age was 6.8 ± 9.5 days. Culture reports identified Klebsiella pneumonia (69%) as the major pathogen. Forty-four percent of neonates died, of whom 57% and 44% suffered early-onset sepsis and late-onset sepsis respectively. Logistic regression showed that mortality was significantly associated with platelet count (OR = 0.998; 95% CI =0.996–1.000) and very low birth weight (LBW) (OR = 2.427; 95% CI = 1.103–5.342). Linear regression showed that the number of definitive antibiotics used was associated with prolonged length of NICU stay. Also, length of NICU stay, number of definitive antibiotics, seizures, and heart disease, were significantly associated with overall cost. Mortality was higher with early-onset of sepsis than with late-onset of sepsis. The study could help policymakers and clinical practitioners to develop and implement targeted interventions that potentially reduce the global prevalence of NS.

Keyword:     Neonatal sepsis early-onset of sepsis mortality length of NICU stay cost


Chandra P, Iqbal F, Unnikrishnan MK, Jayashree P, Shenoy PA, Elstin Anburaj S, Rajesh V, Surulivelrajan M, Lewis LE. Neonatal outcomes associated with antimicrobial resistance: A retrospective cross-sectional study. J Appl Pharm Sci, 2023.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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