Aarthi C, Babu PBR. Anti-cancer activity of Phyllanthus reticulatus on colon cancer cell line. Int J Civ Eng Technol, 2017; 8(1):943- 7.

Abdullah M, Syam AF, Meilany S, Laksono B, Prabu OG, Bekti HS, Indrawati L, Makmun, D. The value of caspase-3 after the application of Annona muricata leaf extract in COLO-205 colorectal cancer cell line. Gastroenterol Res Pract, 2017; 8-13; doi: 10.1155/2017/4357165. https://doi.org/10.1155/2017/4357165

Ahamed MBK, Aisha AFA, Nassar ZD, Siddiqui JM, Ismail Z, Omari SMS, Parish CR, Majid AMSA. Cat's whiskers tea (Orthosiphon stamineus) extract inhibits growth of colon tumor in nude mice and angiogenesis in endothelial cells via suppressing VEGFR phosphorylation. Nutr Cancer, 2012; 64(1):89-99; doi: 10.1080/01635581.2012.630160. https://doi.org/10.1080/01635581.2012.630160

Alam F, Najum us Saqib Q, Waheed A. Cytotoxic activity of extracts and crude saponins from Zanthoxylum armatum DC. against human breast (MCF-7, MDA-MB-468) and colorectal (Caco-2) cancer cell lines. BMC Complement Altern Med, 2017; 17(1):1-9. https://doi.org/10.1186/s12906-017-1882-1

Al-Asmari AK, Albalawi SM, Athar MT, Khan AQ, Al-Shahrani H, Islam M. Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines. PLoS ONE, 2015; 10(8):1-14; doi: 10.1371/ journal.pone.0135814. https://doi.org/10.1371/journal.pone.0135814

Al-Henhena N, Khalifa SAM, Ying RPY, Hassandarvish P, Rouhollahi E, Al-Wajeeh NS, Ali HM, Abdulla MA, El-Seedi HR. Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon. Sci Rep, 2015a; 5:1-13; doi:10.1038/srep13312. https://doi.org/10.1038/srep13312

Al-Henhena N, Khalifa SAM, Ying RPY, Ismail S, Hamadi R, Shawter AN, Idris AM, Azizan A, Al-Wajeeh NS, Abdulla MA, El-Seedi HR. Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo. BMC Complement Altern Med, 2015b; 15(1):1-12; doi:10.1186/s12906-015-0926-7. https://doi.org/10.1186/s12906-015-0926-7

Al-Henhena N, Ying RPY, Ismail S, Najm W, Khalifa SAM, El-Seedi H, Abdulla MA. Chemopreventive efficacy of Andrographis paniculata on azoxymethane-induced aberrant colon crypt foci in vivo. PLoS ONE, 2014; 9(11):1-12; doi:10.1371/journal.pone.0111118. https://doi.org/10.1371/journal.pone.0111118

Al-Nemari R, Al-Senaidy A, Semlali A, Ismael, M, Badjah-Hadj- Ahmed AY, Bacha AB. GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves. BMC Complement Med Ther, 2020; 20(1):1-15; doi:10.1186/ s12906-020-03029-9. https://doi.org/10.1186/s12906-020-03029-9

Almagrami AA, Alshawsh MA, Saif-Ali R, Shwter A, Salem SD, Abdulla MA. Evaluation of chemopreventive effects of Acanthus ilicifolius against azoxymethane-induced aberrant crypt foci in the rat colon. PLoS ONE, 2014; 9(5):1-11; doi:10.1371/journal.pone.0096004. https://doi.org/10.1371/journal.pone.0096004

Amin A, Gani AP, Murwanti R. Cytotoxic activities of (Graptophyllum pictum (l.) Griff) ethanolic extract and its fractions on human colon cancer cell WiDr. Maj Obat Trad, 2020; 25(1):29; doi:10.22146/mot.48189. https://doi.org/10.22146/mot.48189

Ansil PN, Prabha SP, Nitha A, Latha MS. Chemopreventive effect of Amorphophallus campanulatus (Roxb.) blume tuber against aberrant crypt foci and cell proliferation in 1, 2-dimethylhydrazine induced colon carcinogenesis. Asian Pac J Cancer Prev, 2013; 14(9):5331-9; doi:10.7314/APJCP.2013.14.9.5331. https://doi.org/10.7314/APJCP.2013.14.9.5331

Ansil PN, Wills PJ, Varun R, Latha MS. Cytotoxic and apoptotic activities of Amorphophallus campanulatus (Roxb.) Bl. tuber extracts against human colon carcinoma cell line HCT-15. Saudi J Biol Sci, 2014; 21(6):524-31; doi:10.1016/j.sjbs.2014.01.004. https://doi.org/10.1016/j.sjbs.2014.01.004

Arifianti L, Sukardiman, Studiawan H, Rakhmawati Megawati L. Uji aktivitas ekstrak biji sirsak (Annona muricata l.) terhadap sel kanker mamalia secara in vitro. J Farm dan Ilmu Kefarmasian Indones, 2014; 1(2):63-6.

Arora S, Tandon S. Achyranthes aspera root extracts induce human colon cancer cell (COLO-205) death by triggering the mitochondrial apoptosis pathway and s phase cell cycle arrest. Arch Iran Med, 2015; 18(5):284-95; doi:0151805/AIM.006.

Arulselvan P, Wen CC, Lan CW, Chen YH, Wei WC, Yang NS. Dietary administration of scallion extract effectively inhibits colorectal tumor growth: cellular and molecular mechanisms in mice. PLoS ONE, 2012; 7(9):1-14; doi:10.1371/journal.pone.0044658. https://doi.org/10.1371/journal.pone.0044658

Asadi-Samani M, Kooti W, Aslani E, Shirzad H. A systematic review of Iran's medicinal plants with anticancer effects. J Evid Based Complement Altern Med, 2016; 21(2):143-53. Astuti Y, Primasari A. Ethanolic extract of Citrus reticulata peel inhibits the migration of WiDr colon cancer cells. Indones J Cancer Chemoprev, 2020; 11(2):60-6; doi:10.14499/indonesianjcanchemoprev11iss2pp60-66. https://doi.org/10.14499/indonesianjcanchemoprev11iss2pp60-66

Bagheri E, Hajiaghaalipour F, Nyamathulla S, Salehen N. The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation. Drug Des Devel Ther, 2018; 12:657-71; doi:10.2147/DDDT.S155115. https://doi.org/10.2147/DDDT.S155115

Baradaran A, Nasri H, Rafieian-Kopaei M. Oxidative stress and hypertension: possibility of hypertension therapy with antioxidants. J Res Med Sci, 2014; 19:358-67.

Benhalilou N, Alsamri H, Alneyadi A, Athamneh K, Alrashedi A, Altamimi N, Dhaheri YAl, Eid AH, Iratni R. Origanum majorana ethanolic extract promotes colorectal cancer cell death by triggering abortive autophagy and activation of the extrinsic apoptotic pathway. Front Oncol, 2019; 9:1-12; doi:10.3389/fonc.2019.00795. https://doi.org/10.3389/fonc.2019.00795

Budda S, Butryee C, Tuntipopipat S, Rungsipipat A, Wangnaithum S, Lee JS, Kupradinun P. Suppressive effects of Moringa oleifera Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate. Asian Pac J Cancer Prev, 2011; 12(12):3221-8.

Burhan A, Awaluddin A, Zulham Z, Taebe B, Gafur A. Antioxidant and anticancer activities of murbei (Morus alba l.) stem extract on in vitro widr cancer cells. J Pharm Sci Community, 2020; 16(2):63-7; doi:10.24071/jpsc.001698. https://doi.org/10.24071/jpsc.001698

Charepalli V, Reddivari L, Vadde R, Walia S, Radhakrishnan S, Vanamala JKP. Eugenia jambolana (java plum) fruit extract exhibits anti-cancer activity against early stage human HCT-116 colon cancer cells and colon cancer stem cells. Cancers, 2016; 8(3):1-11; doi:10.3390/cancers8030029. https://doi.org/10.3390/cancers8030029

Chari KY, Polu PR, Shenoy RR. An appraisal of pumpkin seed extract in 1, 2-dimethylhydrazine induced colon cancer in wistar rats. J Toxicol, 2018; 2018:1-11; doi:10.1155/2018/6086490. https://doi.org/10.1155/2018/6086490

Chien JH, Lee SC, Chang KF, Huang XF, Chen YT, Tsai NM. Extract of Pogostemon cablin possesses potent anticancer activity against colorectal cancer cells in vitro and in vivo. Evid Based Complement Altern Med, 2020; 2020:1-10; doi:10.1155/2020/9758156. https://doi.org/10.1155/2020/9758156

Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. AAPS J, 2006; 8(2):239-53. https://doi.org/10.1007/BF02854894

Da'i M. Cytotoxic effect of jati belanda leaves towards cancer cell lines. Indones J Cancer Chemoprev, 2015; 6(2):35-41. https://doi.org/10.14499/indonesianjcanchemoprev6iss2pp35-41

Djajanegara I. Uji sitotoksisitas ekstrak ethanol 70 % herba ceplukan (Physalis angulata Linn.) terhadap sel WiDr secara in vitro. J Kim Val, 2008; 1(3):149-56; doi:10.15408/jkv.v1i3.225. https://doi.org/10.15408/jkv.v1i3.225

Endharti AT, Wulandari A, Listyana A, Norahmawati E, Permana S. Dendrophthoe pentandra (L.) Miq extract effectively inhibits inflammation, proliferation and induces p53 expression on colitis-associated colon cancer. BMC Complement Altern Med, 2016; 16(1):1-8; doi:10.1186/s12906-016-1345-0. https://doi.org/10.1186/s12906-016-1345-0

Esghaei M, Ghaffari H, Esboei BR, Tapeh ZE, Salim FB, Motevalian M. Evaluation of anticancer activity of Camellia sinensis in the Caco-2 colorectal cancer cell line. Asian Pac J Cancer Prev, 2018; 19(6):1697-701; doi:10.22034/APJCP.2018.19.6.1697.

Feng J, Jin Y, Peng J, Wei L, Cai Q, Yan Z, Lai Z, Lin J. Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways. Oncol Lett, 2017; 14(6):8197-205; doi:10.3892/ ol.2017.7244.

Globocan. Cancer Incidence in Indonesia. The Global Cancer Observatory, pp 1-2, 2020a. Available via https://gco.iarc.fr/today/fact-sheets-cancers

Globocan. Colorectal Cancer Incidence in The World. The Global Cancer Observatory, 2020b; 1-2. Available via https://gco.iarc.fr/ today/fact-sheets-cancers

Gothai S, Muniandy K, Esa NM, Subbiah SK, Arulselvan P. Anticancer potential of Alternanthera sessilis extract on HT-29 human colon cancer cells. Asian Pac J Trop Biomed, 2018; 8(8):394-402; doi:10.4103/2221-1691.239427. https://doi.org/10.4103/2221-1691.239427

Guizani N, Waly MI, Singh V, Rahman MS. Nabag (Zizyphus spina-christi) extract prevents aberrant crypt foci development in colons of azoxymethane-treated rats by abrogating oxidative stress and inducing apoptosis. Asian Pac J Cancer Prev, 2013; 14(9):5031-5; doi:10.7314/ APJCP.2013.14.9.5031. https://doi.org/10.7314/APJCP.2013.14.9.5031

Hajiaghaalipour F, Kanthimathi MS, Sanusi J, Rajarajeswaran J. White tea (Camellia sinensis) inhibits proliferation of the colon cancer cell line, HT-29, activates caspases and protects DNA of normal cells against oxidative damage. Food Chem, 2015; 169:401-10; doi:10.1016/j. foodchem.2014.07.005. https://doi.org/10.1016/j.foodchem.2014.07.005

Hakim L, Alias E, Makpol S, Ngah WZW, Morad NA, Yusof YAM. Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells. Asian Pac J Cancer Prev, 2014; 15(11):4651-7; doi:10.7314/APJCP.2014.15.11.4651. https://doi.org/10.7314/APJCP.2014.15.11.4651

Haq A, Lobo PI, Al-Tufail M, Rama NR, Al-Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol, 1999; 21(4):284-5. https://doi.org/10.1016/S0192-0561(99)00010-7

Hong GW, Hong SL, Lee GS, Yaacob H, Malek SNA. Non-aqueous extracts of Curcuma mangga rhizomes induced cell death in human colorectal adenocarcinoma cell line (HT29) via induction of apoptosis and cell cycle arrest at G0/G1 phase. Asian Pac J Trop Med, 2016; 9(1):8-18; doi:10.1016/j.apjtm.2015.12.003. https://doi.org/10.1016/j.apjtm.2015.12.003

Hosseini A, Ghorbani A. Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed, 2015; 5(2):84-97; doi:10.22038/ajp.2015.3872.

Hsu CP, Lin CC, Huang CC, Lin YH, Chou JC, Tsia YT, Su JR, Chung YC. Induction of apoptosis and cell cycle arrest in human colorectal carcinoma by litchi seed extract. J Biomed Biotechnol, 2012; 2012:1-6; doi:10.1155/2012/341479. https://doi.org/10.1155/2012/341479

Hu Y, McIntosh GH, Le Leu RK, Somashekar R, Meng XQ, Gopalsamy G, Bambaca L, McKinnon RA, Young GP. Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans. Br J Nutr, 2016; 116(11):1901-11; doi:10.1017/S0007114516003937. https://doi.org/10.1017/S0007114516003937

Indrawati L, Ascobat P, Bela B, Abdullah M, Surono IS. The effect of an Annona muricata leaf extract on nutritional status and cytotoxicity in colorectal cancer: a randomized controlled trial. Asia Pac J Clin Nutr, 2017a; 26(4):606-12; doi:10.6133/apjcn.022016.02.

Indrawati L, Purwantyastuti P, Abdullah M, Surono IS, Basir I. Safety of Annona muricata extract supplementation for colorectal cancer patients. Indones J Gastroenterol Hepatol Dig Endosc, 2017b; 17(3):170; doi:10.24871/1732016170-175. https://doi.org/10.24871/1732016170-175

Jin H, Chen L, Wang S, Chao D. Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway. Tumor Biol, 2017; 39(7):1010428317708699. https://doi.org/10.1177/1010428317708699

Jung J. Human tumor xenograft models for preclinical assessment of anticancer drug development. Toxicol Res, 2014; 30(1):1-5. https://doi.org/10.5487/TR.2014.30.1.001

Kuo TT, Chang HY, Chen TY, Liu BC, Chen HY, Hsiung YC, Hsia SM, Chang CJ, Huang TC. Melissa officinalis extract induces apoptosis and inhibits migration in human colorectal cancer cells. ACS Omega, 2020; 5(49):31792-800; doi:10.1021/acsomega.0c04489. https://doi.org/10.1021/acsomega.0c04489

Kwak Y, Ju J. Glycine max Merr. leaf extract possesses anti-oxidant properties, decreases inflammatory mediator production in murine macrophages, and inhibits growth, migration, and adhesion in human cancer cells. Food Sci Biotechnol, 2017; 26(1):245-53; doi:10.1007/s10068-017- 0033-2. https://doi.org/10.1007/s10068-017-0033-2

Kwak Y, Lee J, Ju J. Anti-cancer activities of Brassica juncea leaves in vitro. EXCLI J, 2016; 15:699-710; doi:10.17179/excli2016-586.

Lai KC, Chiu YJ, Tang YJ, Lin KL, Chiang JH, Jiang YL, Jen HF, Kuo YH, Agamaya S, Chung JG, Yang JS. Houttuynia cordata thunb extract inhibits cell growth and induces apoptosis in human primary colorectal cancer cells. Anticancer Res, 2010; 30(9):3549-56.

Laila F, Fardiaz D, Yuliana ND, Damanik MRM, Dewi FNA. Methanol extract of Coleus amboinicus (Lour) exhibited antiproliferative activity and induced programmed cell death in colon cancer cell WiDr. Int J Food Sci, 2020; 2020:1-11; doi:10.1155/2020/9068326. Lam RY, Woo AY, Leung PS, Cheng CH. Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erthrocytes in vitro. J Am Coll Nutr, 2007; 26:233-42. https://doi.org/10.1080/07315724.2007.10719606

Lauricella M, Galbo VL, Cernigliaro C, Maggio A, Piccionello AP, Calvaruso G, Carlisi D, Emanuele S, Giuliano M, D'Anneo A. The anti-cancer effect of Mangifera indica L. peel extract is associated to γH2Ax-mediated apoptosis in colon cancer cells. Antioxidants, 2019; 8(10):1-18; doi:10.3390/antiox8100422. https://doi.org/10.3390/antiox8100422

Leboe DW, Ningsi S, Fiqardina A. Uji sitotoksik ekstrak n-heksan daun botto'-botto' (Chromolaena odorata L.) terhadap cell line kanker kolon WiDr. J Kesehat, 2005; 10(2):82-4.

Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY. Momordica charantia extract induces apoptosis in human cancer cells through caspase-and mitochondria-dependent pathways. Evid Based Complement Altern Med, 2012; 2012:1-9; doi:10.1155/2012/261971. https://doi.org/10.1155/2012/261971

Lian G, Li F, Yin Y, Chen L, Yang J. Herbal extract of Artemisia vulgaris (mugwort) induces antitumor effects in HCT-15 human colon cancer cells via autophagy induction, cell migration suppression and loss of mitochondrial membrane potential. J BUON, 2018; 23(1):73-8.

Lima A, Batista-Santos P, Veríssimo E, Rebelo P, Ferreira RB. Differential inhibition of gelatinase activity in human colon adenocarcinoma cells by Aloe vera and Aloe arborescens extracts. BMC Complement Med Ther, 2020; 20(1):1-11; doi:10.1186/s12906-020-03134-9. https://doi.org/10.1186/s12906-020-03134-9

Lin J, Wei L, Shen A, Cai Q, Xu W, Li H, Zhan Y, Hong Z, Peng J. Hedyotis diffusa Willd extract suppresses sonic hedgehog signaling leading to the inhibition of colorectal cancer angiogenesis. Int J Oncol, 2013; 42(2):651-6; doi:10.3892/ijo.2012.1753. https://doi.org/10.3892/ijo.2012.1753

Lin J, Wei L, Xu W, Hong Z, Liu X, Peng J. Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis. Mol Med Rep, 2011; 4(6):1283-8; doi:10.3892/mmr.2011.577. https://doi.org/10.3892/mmr.2011.577

Lu PH, Chen MB, Ji C, Li WT, Wei MX, Wu MH. Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings. Oncotarget, 2016; 7(29):45889- 900; doi:10.18632/oncotarget.9969. https://doi.org/10.18632/oncotarget.9969

Madihi Y, Merrikhi A, Baradaran A, Rafieian-Kopaei M, Fard S, Ansari Samani R, Mesripour A. Impact of Sumac on postprandial high-fat oxidative stress. Pak J Med Sci, 2013; 29(S):340-5. https://doi.org/10.12669/pjms.291(Suppl).3529

Maruti AA, Ilham Augusta F, Putri DDP, Hermawan A, Ikawati M. The cytotoxic activity of Solanum nigrum ethanolic extract on widr human colon cancer cells. Indones J Cancer Chemoprev, 2011; 2(3):291; doi:10.14499/indonesianjcanchemoprev2iss3pp291-294. https://doi.org/10.14499/indonesianjcanchemoprev2iss3pp291-294

Matsuura N, Miyamae Y, Yamane K, Nagao Y, Hamada Y, Kawaguchi N, Katsuki T, Hirata K, Sumi SI, Ishikawa H. Aged garlic extract inhibits angiogenesis and proliferation of colorectal carcinoma cells. J Nutr, 2006; 136(3):842-6; doi:10.1093/jn/136.3.v. https://doi.org/10.1093/jn/136.3.v

Meiftasari A, Januar Caesar WP, Novarina A, Julika Yovi W, Jenie RI. Ethanolic extract of Hedyotis corymbosa and its combination with 5-FU inhibit cyclin d expression on WiDr colorectal cancer cell. Indones J Cancer Chemoprev, 2016; 7(1):25-9; doi:10.14499/indonesianjcanchemoprev7iss1pp25-30. https://doi.org/10.14499/indonesianjcanchemoprev7iss1pp25-30

Mesquita LSS, Luz TRSA, de Mesquita JWC, Coutinho DF, Amaral FMM do, Ribeiro, MNS de, Malik S. Exploring the anticancer properties of essential oils from family Lamiaceae. Food Rev Int, 2019; 35(2):105-31. https://doi.org/10.1080/87559129.2018.1467443

Moghadamtousi SZ, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, Abdul Kadir H. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol, 2014; 156:277-89; doi:10.1016/j.jep.2014.08.011. https://doi.org/10.1016/j.jep.2014.08.011

Moghadamtousi SZ, Rouhollahi E, Karimian H, Fadaeinasab M, Firoozinia M, Abdulla MA, Kadir HA. The chemopotential effect of Annona muricata leaves against azoxymethane-induced colonic aberrant crypt foci in rats and the apoptotic effect of acetogenin annomuricin e in TH-29 cells - a bioassay-guided approac. PLoS ONE, 2015; 10(4):1-28; doi:10.1371/journal.pone.0122288. https://doi.org/10.1371/journal.pone.0122288

Mohammadi A, Mansoori B, Aghapour M, Baradaran PC, Shajari N, Davudian S, Salehi S, Baradaran B. The herbal medicine Utrica dioica inhibits proliferation of colorectal cancer cell line by inducing apoptosis and arrest at the g2/m phase. J Gastrointest Cancer, 2016; 47(2):187-95; doi:10.1007/s12029-016-9819-3. https://doi.org/10.1007/s12029-016-9819-3

Mutiah R, Firsyaradha WY, Sari RA, Annisa R, Kristanti RA, Indrawijaya YYA, Griana TP, Listiyana A. Eleutherine palmifolia (L.) Merr. extract increases the crypts and caspase-3 expression in colitis-associated colon cancer model. Indones J Pharm, 2020a; 31(4):257-65; doi:10.22146/ ijp.1120. https://doi.org/10.22146/ijp.1120

Mutiah R, Kirana FO, Annisa R, Rahmawati A, Sandra F. Extract of yellow root (Arcangelisia flava (L.) Merr.) from several regions in kalimantan: alkaloid content and cytotoxicity towards widr colorectal cancer cells. Indones J Cancer Chemoprev, 2020b; 11(2):84-8; doi:10.14499/ indonesianjcanchemoprev11iss2pp84-89. https://doi.org/10.14499/indonesianjcanchemoprev11iss2pp84-89

Mutiah R, Sari RA, Firsyaradha WY, Listiyana A, Ari Indrawijaya YY, Wafi A, Suryadinata A, Susilowati R, Rahmawati A. Activity and toxicity of Eleutherine palmifolia (L.) Merr. extract on balb/c mice colitis-associated colon cancer model. Asian Pac J Cancer Prev, 2020c; 21(12):3579-86; doi:10.31557/APJCP.2020.21.12.3579. https://doi.org/10.31557/APJCP.2020.21.12.3579

Narayanan NK, Kunimasa K, Yamori Y, Mori M, Mori H, Nakamura K, Miller G, Manne U, Tiwari AK, Narayanan B. Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo. Cancer Med, 2015; 4(11):1767-80; doi:10.1002/cam4.520. https://doi.org/10.1002/cam4.520

Nasir NLM, Kamsani NE, Mohtarrudin N, Othman F, Tohid SFM, Zakaria ZA. Anticarcinogenic activity of Muntingia calabura leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids. Pharm Biol, 2017; 55(1):2102-9; doi:10.1080/13880209.2017.1371769. https://doi.org/10.1080/13880209.2017.1371769

Nelson VK, Sahoo NK, Sahu M, Sudhan HH, Pullaiah CP, Muralikrishna KS. In vitro anticancer activity of Eclipta alba whole plant extract on colon cancer cell HCT-116. BMC Complement Med Ther, 2020; 20(1):1-9; doi:10.1186/s12906-020-03118-9. https://doi.org/10.1186/s12906-020-03118-9

Nourazarian SM, Nourazarian A, Majidinia M, Roshaniasl E. Effect of root extracts of medicinal herb Glycyrrhiza glabra on HSP90 gene expression and apoptosis in the HT-29 colon cancer cell line. Asian Pac J Cancer Prev, 2016; 16(18):8563-6; doi:10.7314/APJCP.2015.16.18.8563. https://doi.org/10.7314/APJCP.2015.16.18.8563

Nurulita NA, Meiyanto E, Sugiyanto S. Selectivity of ethyl acetate fraction of Gynura procumbens on colon cancer and breast cancer. Indones J Cancer Chemoprev, 2011; 2(3):274-9; doi:10.14499/ indonesianjcanchemoprev2iss3pp274-280. https://doi.org/10.14499/indonesianjcanchemoprev2iss3pp274-280

Nussbaumer S, Bonnabry P, Veuthey JL, Fleury-Souverain S. Analysis of anticancer drugs: a review. Talanta, 2011; 85:2266; doi 10.1016/j.talanta.2011.08.034. https://doi.org/10.1016/j.talanta.2011.08.034

Ovadje P, Ammar S, Guerrero JA, Arnason JT, Pandey S. Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 2016; 7(45):73080-100; doi:10.18632/oncotarget.11485. https://doi.org/10.18632/oncotarget.11485

Ovadje P, Ma D, Tremblay P, Roma A, Steckle M, Guerrero JA, Arnason JT, Pandey S. Evaluation of the efficacy & biochemical mechanism of cell death induction by Piper longum extract selectively in in-vitro and in-vivo models of human cancer cells. PLoS ONE, 2014; 9(11):1-15; doi:10.1371/journal.pone.0113250. https://doi.org/10.1371/journal.pone.0113250

Özgen U, Mavi A, Terzi Z, Yildirim A, Co?kun M, Houghton PJ. Antioxidant properties of some medicinal Lamiaceae (Labiatae) species. Pharm Biol, 2006; 44(2):107-8. https://doi.org/10.1080/13880200600592061

Pahari B, Chakraborty S, Chaudhuri S, Sengupta B, Sengupta PK. Binding and antioxidant properties of therapeutically important plant flavonoids in biomembranes: insights from spectroscopic and quantum chemical studies. Chem Phys Lipids, 2012; 165:488-96. https://doi.org/10.1016/j.chemphyslip.2011.10.006

Palmieri A, Scapoli L, Iapichino A, Mercolini L, Mandrone M, Poli F, Giannì AB, Baserga C, Martinelli M. Berberine and Tinospora cordifolia exert a potential anticancer effect on colon cancer cells by acting on specific pathways. Int J Immunopathol Pharmacol, 2019; 33:1-10; doi:10.1177/2058738419855567. https://doi.org/10.1177/2058738419855567

Park CH, Kim MJ, Yang CY, Yokozawa T, Shin YS. Safflower seed extract synergizes the therapeutic effect of cisplatin and reduces cisplatin-induced nephrotoxicity in human colorectal carcinoma RKO cells and RKO-transplanted mice. Drug Discov Ther, 2019; 13(6):328-34; doi:10.5582/ddt.2019.01086. https://doi.org/10.5582/ddt.2019.01086

Park GH, Park JH, Song HM, Eo HJ, Kim MK, Lee JW, Lee MH, Cho KH, Lee JR, Cho HJ, Jeong JB. Anti-cancer activity of ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells. BMC Complement Altern Med, 2014a; 14(408):1-7; doi:10.1186/1472-6882-14-408. https://doi.org/10.1186/1472-6882-14-408

Park GH, Song HM, Park SB, Son HJ, Um Y, Kim HS, Jeong JB. Cytotoxic activity of the twigs of Cinnamomum cassia through the suppression of cell proliferation and the induction of apoptosis in human colorectal cancer cells. BMC Complement Altern Med, 2018; 18(1):1-13; doi:10.1186/s12906-018-2096-x. https://doi.org/10.1186/s12906-018-2096-x

Park KW, Kundu J, Chae IG, Bachar SC, Bae JW, Chun KS. Methanol extract of Flacourtia indica aerial parts induces apoptosis via generation of ROS and activation of caspases in human colon cancer HCT116 cells. Asian Pac J Cancer Prev, 2014b; 15(17):7291-6; doi:10.7314/ APJCP.2014.15.17.7291. https://doi.org/10.7314/APJCP.2014.15.17.7291

Park SB, Park GH, Song HM, Son HJ, Um Y, Kim HS, Jeong JB. Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells. BMC Complement Altern Med, 2017; 17(1):1-10; doi:10.1186/s12906-017- 1954-2. https://doi.org/10.1186/s12906-017-1954-2

Pavarini DP, Pavarini SP, Niehues M, Lopes NP. Exogenous influences on plant secondary metabolite levels. Anim Feed Sci Technol, 2012; 176(1-4):5-7; doi: 10.1016/j.anifeedsci.2012.07.002 https://doi.org/10.1016/j.anifeedsci.2012.07.002

Perše M, Cerar A. Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol, 2010; 2011: 1-10, doi:10.1155/2011/473964. https://doi.org/10.1155/2011/473964

Rahayu M, Roosmarinto R. Kajian aktivitas antikanker ekstrak daun gude (Cajanus cajan) terhadap sel kanker kolon secara in vitro. J Teknol Lab, 2017; 6(1):31-7; doi:10.29238/teknolabjournal.v6i1.87. https://doi.org/10.29238/teknolabjournal.v6i1.87

Rakasiwi MID, Kusmardi K, Estuningtyas A, Tedjo A. Potential of ethanol extract of mahkota dewa leaves (Phaleria macrocarpa (Schecff.) Boerl.) to inhibit inflammation in mouse distal colon induced by dextran sodium sulfate (DSS) and azoxymethane (AOM). Int J Appl Pharm, 2020; 12(3):101-5; doi:10.22159/ijap.2020.v12s3.39490. https://doi.org/10.22159/ijap.2020.v12s3.39490

Rivanti E, Shabrina BA, Nurzijah I, Ayu C, Hermawan A. Heartwood of secang (Caesalpinia sappan L.) ethanolic extract show selective cytotoxic activities on T47D and WiDr cells but not on Hela cells. Indones J Cancer Chemoprev, 2017; 7(2):60; doi:10.14499/ indonesianjcanchemoprev7iss2pp60-67. https://doi.org/10.14499/indonesianjcanchemoprev7iss2pp60-67

Rohmah AL, Amalia F, Rivanti E, Putri DDP, Nurulita NA. Cytotoxic activity and apoptosis induction of ethanolic extract of pericarps of mangosteen (Garcinia mangostana linn.) on WiDr cells and interaction study of alpha-mangosteen to ikk and vegf based on molecular docking. Indones J Cancer Chemoprev, 2013; 4(1):470; doi:10.14499/ indonesianjcanchemoprev4iss1pp470-476. https://doi.org/10.14499/indonesianjcanchemoprev4iss1pp470-476

Roma A, Ovadje P, Steckle M, Nicoletti L, Saleem A, Arnason JT, Pandey S. Selective induction of apoptosis by Azadarichta indica leaf extract by targeting oxidative vulnerabilities in human cancer cells. J Pharm Pharm Sci, 2015; 18(4):729-46; doi:10.18433/J3VG76. https://doi.org/10.18433/J3VG76

Rouhollahi E, Moghadamtousi SZ, Paydar M, Fadaeinasab M, Zahedifard M, Hajrezaie M, Hamdi OAA, Looi CY, Abdulla MA, Awang K, Mohamed Z. Inhibitory effect of Curcuma purpurascens BI. rhizome on HT-29 colon cancer cells through mitochondrial-dependent apoptosis pathway. BMC Complement Altern Med, 2015a; 15(1):1-12; doi:10.1186/ s12906-015-0534-6. https://doi.org/10.1186/s12906-015-0534-6

Rouhollahi E, Moghadamtousi ZS, Al-Henhena N, Kunasegaran T, Hasanpourghadi M, Looi, CY, Malek SNA, Awang K, Abdulla MA, Mohamed Z. The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats. Drug Des Devel Ther, 2015b; 9:3911-22; doi:10.2147/DDDT.S84560. https://doi.org/10.2147/DDDT.S84560

Ruvinov I, Nguyen C, Scaria B, Vegh C, Zaitoon O, Baskaran K, Mehaidli A, Nunes M, Pandey S. Lemongrass extract possesses potent anticancer activity against human colon cancers, inhibits tumorigenesis, enhances efficacy of FOLFOX, and reduces its adverse effects. Integr Cancer Ther, 2019; 18:1-13; doi:10.1177/1534735419889150. https://doi.org/10.1177/1534735419889150

Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci, 2008; 65(19):2979-99. https://doi.org/10.1007/s00018-008-8103-5

Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S. Potential anticancer effect of red spinach (Amaranthus gangeticus) extract. Asia Pac J Clin Nutr, 2004; 13(4):396-400; doi:10.1111/(ISSN)1440-6047/.

Setiawati A, Immanuel H, Utami MT. The inhibition of Typhonium flagelliforme Lodd. Blume leaf extract on COX-2 expression of WiDr colon cancer cells. Asian Pac J Trop Biomed, 2016; 6(3):251-5; doi:10.1016/j.apjtb.2015.12.012. https://doi.org/10.1016/j.apjtb.2015.12.012

Sharma V, Hussain S, Gupta M, Saxena AK. In vitro anticancer activity of extracts of Mentha spp. against human cancer cells. Indian J Geo Marine Sci, 2014; 51(5):416-9.

Shimizu M, Fukutomi Y, Ninomiya M, Nagura K, Kato T, Araki H, Suganuma M, Fujiki H, Moriwaki H. Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev, 2008; 17(11):3020-5; doi:10.1158/1055-9965.EPI-08-0528. https://doi.org/10.1158/1055-9965.EPI-08-0528

Shwter AN, Abdullah NA, Alshawsh MA, Alsalahi A, Hajrezaei M, Almaqrami AA, Salem SD, Abdulla MA. Chemoprevention of colonic aberrant crypt foci by Gynura procumbens in rats. J Ethnopharmacol, 2014; 151(3):1194-201; doi:10.1016/j.jep.2013.12.044. https://doi.org/10.1016/j.jep.2013.12.044

Son ES, Kim YO, Park CG, Park KH, Jeong SH, Park JW, Kim SH. Coix lacryma-jobi var. ma-yuen Stapf sprout extract has anti-metastatic activity in colon cancer cells in vitro. BMC Complement Altern Med, 2017; 17(1):1-9; doi:10.1186/s12906-017-1990-y. https://doi.org/10.1186/s12906-017-1990-y

Sreedharan V, Venkatachalam KK, Namasivayam N. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs, 2009; 27(1):21-30. https://doi.org/10.1007/s10637-008-9136-1

Susanty A, Dachriyanus D, Yanwirasti Y, Wahyuni FS, Fadhli H, Aswan PA. Aktivitas sitotoksik ekstrak etil asetat daun tampa badak (Voacanga foetida (Bl.)K.Schum) pada kanker kolon HTB-38. J Sains Farm Klin, 2018; 5(2):142-6. https://doi.org/10.25077/jsfk.5.2.142-146.2018

Sutrisna IWW, Sudartana K, Widiana GR. Correlation between histopathologic grading and carcinoembryonic antigen levels in colon carcino. Medicina, 2018; 49(1):22-8; doi:10.15562/medicina.v49i1.256. https://doi.org/10.15562/medicina.v49i1.256

Tanaka S, Haruma K, Yoshihara M, Kajiyama G, Kira K, Amagase H, Chayama K. Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr, 2006; 136(3):821-6; doi:10.1093/jn/136.3.v. https://doi.org/10.1093/jn/136.3.v

Tang Y, Yang J, Lin C, Shyu W, Tsuzuki M, Lu C, Chen Y, Lai K. Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells. Oncol Rep, 2010; 31(12):1265-70; doi:10.3892/or. https://doi.org/10.3892/or

Tsao AS, Kim ES, Hong WK. Chemoprevention of cancer. Carcinogenesis, 2000; 21(3):525-30; doi:10.1093/carcin/21.3.525. https://doi.org/10.1093/carcin/21.3.525

Uyar A, Do?an A, Yaman T, Kele? ÖF, Yener Z, Çelik ?, Alkan EE. The protective role of Urtica dioica seed extract against azoxymethane-induced colon carcinogenesis in rats. Nutr Cancer, 2021; 1-11; doi:10.1080 /01635581.2021.1881568. https://doi.org/10.1080/01635581.2021.1881568

Venkateshappa S, Sreenath K. Potential medicinal plants of lamiaceae. Am Int J Res Formal Appl Nat Sci, 2013; 3(1):82.

Wang ZY, Liu HP, Zhang YC, Guo LQ, Li ZX, Shi XF. Anticancer potential of Euphorbia helioscopia L. extracts against human cancer cells. Anat Rec, 2012; 295(2):223-33; doi:10.1002/ar.21517. https://doi.org/10.1002/ar.21517

Weidner C, Rousseau M, Plauth A, Wowro SJ, Fischer C, Abdel-Aziz H, Sauer S. Melissa officinalis extract induces apoptosis and inhibits proliferation in colon cancer cells through formation of reactive oxygen species. Phytomedicine, 2015; 22(2):262-70; doi:10.1016/j. phymed.2014.12.008. https://doi.org/10.1016/j.phymed.2014.12.008

Wong YH, Tan WY, Tan CP, Long K, Nyam KL. Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines. Asian Pac J Trop Biomed, 2014; 4(1):510-5; doi:10.12980/APJTB.4.2014C1090. https://doi.org/10.12980/APJTB.4.2014C1090

Wulandari N, Meiftasari A, Fadliyah H, Jenie RI. Red betel leaves methanolic extract (Piper crocatum ruiz & pav.) increases cytotoxic effect of doxorubicin on WiDr colon cancer cells through apoptosis induction. Indones J Cancer Chemoprev, 2018; 9(1):1-7; doi:10.14499/ indonesianjcanchemoprev9iss1pp1-8. https://doi.org/10.14499/indonesianjcanchemoprev9iss1pp1-8

Yan Z, Feng J, Peng J, Lai Z, Zhang L, Jin Y, Yang H, Chen W, Lin J. Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. Oncol Lett, 2017; 14(6):7923-30; doi:10.3892/ol.2017.7245. Yusof YA, Abdullah S, Sahardi NF, Wan WZ, Makpol NS. Zingiber officinale and Piper betle extracts enhanced the chemopreventive effect against colon cancer cells by targeting caspase-mediated apoptosis. Sains Malays, 2022; 51(1):217-37.

Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright BD, Alrawi S, Normolle DP, Djuric Z, Brenner DE. Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prev Res, 2011; 4(11):1929-37; doi:10.1158/1940-6207.CAPR-11-0224. https://doi.org/10.1158/1940-6207.CAPR-11-0224