Potential sources of chemopreventive agents from Indonesian plants against colorectal cancer: A review

Maria Immaculata Iwo Muhammad Andhika Alfaridzi Hubbi Nashurullah Muhammad   

Open Access   

Published:  Dec 13, 2022

DOI: 10.7324/JAPS.2023.94509
Abstract

Colorectal cancer (CRC) is a serious health problem worldwide. The ever-increasing cases encouraged researchers to discover more effective novel drugs from plant sources. In this review, we summarized the plants contributing to the chemoprevention of CRC, as reported in in vitro animal studies and clinical trials. A literature search was conducted to collect information regarding the biological activities of plants from PubMed and Google Scholar, and also hand searching from other literature databases. 77 plants of 47 families cultivated in Indonesia were introduced as candidates for chemopreventive agents that help reduce cancer proliferation, progression, or recurrence. Phenolic compounds were revealed to have anticancer effects in most studies. Allium sativum L., Zingiber officinale Roscoe, Annona muricata L., and Camellia sinensis (L.) Kuntze, the fourth Indonesian plant only in a clinical trial, was able to reduce the risk of recurrence of colon adenoma, safe, and tolerated. Therefore, this review article could be key to conducting clinical trials on other plants to evaluate the safety and efficacy of developing new anticancer drugs against CRC.


Keyword:     Cancer chemoprevention chemopreventive agents colorectal cancer Indonesian plants


Citation:

Iwo MI, Alfaridzi MA, Muhammad HN. Potential sources of chemopreventive agents from Indonesian plants against colorectal cancer: A review. J Appl Pharm Sci, 2022. https://doi.org/10.7324/JAPS.2023.94509

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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