Evaluation of knowledge, attitude, and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India

Gottipati Naga Haritha; Annamalai Rama; Anup Naha; Usha Rani

Abstract

This study aims to assess medical and dental postgraduates’ knowledge, attitude, and practice (KAP) toward reporting adverse drug reactions (ADRs) and compare the KAP between the medical and dental postgraduates. A cross-sectional questionnaire-based study was conducted on 208 postgraduates (medical and dental postgraduates combined). The medical postgraduates belong to a tertiary care teaching hospital that is 2,000 bedded, serving a population of 1,177,361 in the southwest part of Karnataka, whereas the Dental postgraduates belong to teaching Dental hospitals from the same region as the above hospital received their accreditation by the Dental Council of India in 1970. Both the postgraduates had low KAP about the reporting system of ADRs and the ADR reporting system situated in this hospital. This study also found that the majority of the postgraduates had not attended the training sessions regarding the reporting of ADRs. This study concludes that the ADR reporting is crucial for all healthcare providers so that it initiates the exact actions by healthcare providers through which adverse events can be prevented, and will help in better drug management and thus the reputation of the hospital can be upgraded.

Keyword: Pharmacovigilance adverse drug reactions pharmaceuticals healthcare professionals.

Citation:

Haritha GN, Rama A, Naha A, Rani U. Evaluation of knowledge, attitude and practice of medical and dental postgraduates toward reporting of adverse drug reactions in a teaching hospital, South India. J Appl Pharm Sci, 2022. Online First.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reference

Alsaleh FM, Alzaid SW, Abahussain EA, Bayoud T, Lemay J. Knowledge, attitude and practices of pharmacovigilance and adverse drug reaction reporting among pharmacists working in secondary and tertiary governmental hospitals in Kuwait. Saudi Pharm J, 2017; 25:830-7. https://doi.org/10.1016/j.jsps.2016.12.004

Amin A, Malik M, Hussain A. Evolving trends and future prospects of adr monitoring and reporting: a literature review. Asian J Pharm Clin Res, 2016; 9:126. https://doi.org/10.22159/ajpcr.2016.v9i5.12725

Ashraf Tadvi N, Alromaih AA, Aldahash AA, Almuhesseny AA, Alotaibi SH, Alduhayshi IS, Alrukimi AS, Sami W. Knowledge, attitude and practice of pharmacovigilance in healthcare professionals and medical students in Majmaah, Saudi Arabia Care Centre. Int J Med Res Heal Sci, 2018; 7:101-7.

Avery A, Anderson C, Bond C, Fortnum H, Gifford A, Hannaford PC, Hazell L, Krska J, Lee AJ, McLernon DJ, Murphy E, Shakir S, Watson MC. Evaluation of patient reporting of adverse drug reactions to the UK "Yellow Card Scheme": literature review, descriptive and qualitative analyses, and questionnaire surveys. Health Technol Assess (Rockv), 2011; 15. https://doi.org/10.3310/hta15200

Bisht M, Singh S, Dhasmana DC. Effect of educational intervention on adverse drug reporting by physicians: a cross-sectional study. ISRN Pharmacol, 2014; 2014:1-8. https://doi.org/10.1155/2014/259476

Borg JJ, Tanti A, Kouvelas D, Lungu C, Pirozynski M, SerracinoInglott A, Aislaitner G. European Union pharmacovigilance capabilities: potential for the new legislation. Ther Adv Drug Saf, 2015; 6:120-40. https://doi.org/10.1177/2042098615591802

Bahri C. How India tackles adverse drug reactions-by ignoring data. India Spend, pp 1-5, 2016. Available via https://www.indiaspend. com/how-india-tackles-adverse-drug-reactions-by-ignoring-data-45036/ (Accessed 15 March 2022).

Cleveland LM. Parenting in the neonatal intensive care unit. JOGNN-J Obstet Gynecol Neonatal Nurs, 2008; 37:666-91. https://doi.org/10.1111/j.1552-6909.2008.00288.x

Dhamija P, Kalra S, Sharma PK, Kalaiselvan V, Muruganathan A, Balhara YPS, Badani R, Bantwal G, Das AK, Dhorepatil B, Ghosh S, Jeloka T, Khandelwal D, Nadkar MY, Patnaik KP, Saboo B, Sahay M, Sahay R, Tiwaskar M, Unnikrishnan AG. Indian College of Physicians (ICP) position statement on pharmacovigilance. J Assoc Physicians India, 2017; 65:63.

Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet, 2000; 356:1255-9. https://doi.org/10.1016/S0140-6736(00)02799-9

Fadare J, Enwere O, Afolabi A, Chedi B, Musa A. Knowledge, attitude and practice of adverse drug reaction reporting among healthcare workers in a tertiary centre in Northern Nigeria. Trop J Pharm Res, 2011; 10:235-42. https://doi.org/10.4314/tjpr.v10i3.4

Ghewari PS, Salunkhe SS, Bhatia N, Killedar SG. Strategies and current scenario of Pharamcovigilance in India. J Adv Drug Deliv, 2014; 1:122-34.

Giofrè C, Scicchitano F, Palleria C, Mazzitello C, Ciriaco M, Gallelli L, Paletta L, Marrazzo G, Leporini C, Ventrice P, Carbone C, Saullo F, Rende P, Menniti M, Mumoli L, Chimirri S, Patanè M, Esposito S, Cilurzo F, Staltari O, Russo E, De Sarro G; UNIVIGIL CZ Group. Pharmacovigilance and drug safety in Calabria (Italy): 2012 adverse events analysis. J Pharmacol Pharmacother, 2013; 4:55. https://doi.org/10.4103/0976-500X.120963

Van Grootheest AC, de Jong-van den Berg LTW. The role of hospital and community pharmacists in pharmacovigilance. Res Soc Adm Pharm, 2005; 1:126-33. https://doi.org/10.1016/j.sapharm.2004.12.009

Van Grootheest K. The dawn of pharmacovigilance: an historical perspective. Int J Pharm Med, 2003; 17:195-200. https://doi.org/10.2165/00124363-200317050-00006

Jeetu G, Anusha G. Pharmacovigilance: a worldwide master key for drug safety monitoring. J Young Pharm, 2010; 2:315-20. https://doi.org/10.4103/0975-1483.66802

Khan S, Goyal C, Tonpay S. A study of knowledge, attitudes, and practice of dental doctors about adverse drug reaction reporting in a teaching hospital in India. Perspect Clin Res, 2015; 6:144. https://doi.org/10.4103/2229-3485.159938

Kharkar M, Bowalekar S. Knowledge, attitude and perception/ practices (KAP) of medical practitioners in India towards adverse drug reaction (ADR) reporting. Perspect Clin Res, 2012; 3:90. https://doi.org/10.4103/2229-3485.100651

Khjauria V, Tandon VR, Rani N, Roshi, Gupta S, Choudhary S, Gilllani Z. Profile of adverse drug reactions with fixed drug combinations: how big is the problem? JK Sci, 2015; 17:33-7.

Kumar A. Past, present and future of pharmacovigilance in India. Syst Rev Pharm, 2011; 2:55. https://doi.org/10.4103/0975-8453.83440

Masurkar PP. A need of better pharmacovigilance system in India. Asian J Pharm Clin Res, 2017; 10:22-4. https://doi.org/10.22159/ajpcr.2017.v10i1.14797

Mehta Y, Gupta A, Todi S, Myatra SN, Samaddar DP, Patil V, Bhattacharya PK, Ramasubban S . Guidelines for prevention of hospital acquired infections. Indian J Crit Care Med, 2014; 18:149-63. https://doi.org/10.4103/0972-5229.128705

Mittal N, Mittal R, Gupta MC. An overview of the pharmacovigilance system in India. Clin Res Regul Aff, 2016; 33:4-8. https://doi.org/10.3109/10601333.2016.1127381

Tew MM, Teoh BC, Mohd Baidi AS, Saw HL. Assessment of knowledge, attitude and practices of adverse drug reaction reporting among doctors and pharmacists in primary healthcare. Adv Pharmacoepidemiol Drug Saf, 2016; 5:1-6. https://doi.org/10.4172/2167-1052.1000206

Opadeyi AO, Fourrier-Réglat A, Isah AO. Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators. BMC Pharmacol Toxicol, 2018; 19:27. https://doi.org/10.1186/s40360-018-0217-2

Peymani P, Tabrizi R, Afifi S, Namazi S, Heydari ST, Shirazi MK, Nouraei H, Sadeghi E, Lankarani KB, Maharlouei N. Knowledge, attitude and practice of General Practitioners towards adverse drug reaction reporting in South of Iran, Shiraz (Pharmacoepidemiology report). Int J Risk Saf Med, 2016; 28:25-31. https://doi.org/10.3233/JRS-160670

Pinto A, Caranci F, Romano L, Carrafiello G, Fonio P, Brunese L. Learning from errors in radiology: a comprehensive review. Semin Ultrasound, CT MRI, 2012; 33:379-82. https://doi.org/10.1053/j.sult.2012.01.015

Prerna Upadhyaya P, Seth V, Sharma, Moghe. Knowledge of adverse drug reaction reporting in first year postgraduate doctors in a medical college. Ther Clin Risk Manag, 2012; 8:307. https://doi.org/10.2147/TCRM.S31482

Rajesh R, Vidyasagar S, Varma DM. An educational intervention to assess knowledge attitude practice of pharmacovigilance among health care professionals in an Indian tertiary care teaching hospital. Int J PharmTech Res, 2011; 3:678-92.

Ridings JE. The Thalidomide disaster, lessons from the past (Chapter 36), 2013. https://doi.org/10.1007/978-1-62703-131-8_36

Rosenberg RE, Devins L, Geraghty G, Bock S, Dugan CA, Transou M, Phillips M, Lighter-Fisher J. Engaging frontline staff in central line-associated bloodstream infection prevention practice in the wake of superstorm sandy. Jt Comm J Qual Patient Saf, 2015; 41:462-8. https://doi.org/10.1016/S1553-7250(15)41060-8

Patil JS. Pharmacovigilance in India. J Pharmacovigil, 2014; 02:56. https://doi.org/10.4172/2329-6887.1000e119

Sanghavi DR, Dhande PP, Pandit VA. Perception of pharmacovigilance among doctors in a tertiary care hospital: influence of an interventional lecture. Int J Risk Saf Med, 2013; 25:197-204. https://doi.org/10.3233/JRS-130598

Shamim S, Sharib SM, Malhi SM, Muntaha S, Raza H, Ata S, Farooq AS, Hussain M. Adverse drug reactions ( ADRS ) reporting : awareness and reasons of under-reporting among health care professionals , a challenge for pharmacists. Springerplus, 2016; 5(1):1778. https://doi.org/10.1186/s40064-016-3337-4

Sharma A, Chhabra KG, Chhabra C, Reddy JJ, Deolia SG, Mittal Y. Knowledge, attitude, and practices regarding pharmacovigilance and adverse drug reaction reporting among dental students in a Teaching Hospital, Jodhpur, India: a cross-sectional study. J Contemp Dent Pract, 2017; 18:964-9. https://doi.org/10.5005/jp-journals-10024-2157

Stergiopoulos S, Brown CA, Felix T, Grampp G, Getz KA. A survey of adverse event reporting practices among US healthcare professionals. Drug Saf, 2016; 39:1117-27. https://doi.org/10.1007/s40264-016-0455-4

Varallo FR, Guimarães S de OP, Abjaude SAR, Mastroianni P de C. Causes for the underreporting of adverse drug events by health professionals: a systematic review. Rev Da Esc Enferm Da USP, 2014; 48:739-47. https://doi.org/10.1590/S0080-623420140000400023

Vashisth S, Singh G, Nanda A. A comparative study of regulatory trends of pharmaceuticals in Brazil, Russia, India and China (BRIC) countries. J Generic Med, 2012; 9:128-43. https://doi.org/10.1177/1741134312459187

Vivekanandan K. System of adverse drug reactions reporting: what, where, how, and whom to report? Indian J Crit Care Med, 2015; 19:564-6. https://doi.org/10.4103/0972-5229.164819

Vora M, Nagar J, Patel P, Upadhyaya H. Knowledge, attitude and practices toward pharmacovigilance and adverse drug reactions in postgraduate students of Tertiary Care Hospital in Gujarat. J Adv Pharm Technol Res, 2015; 6:29. https://doi.org/10.4103/2231-4040.150369

Zaka UN, Ayesha Zafar FS. Assessment of knowledge, attitude and practice of adverse drug reaction reporting among healthcare professionals in secondary and tertiary hospitals in the capital of Pakistan. Saudi Pharm J, 2018; 26:453-61. https://doi.org/10.1016/j.jsps.2018.02.014

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